Thiotaurine
INCI: THIOTAURINE
Reviewed by Daisy · Last updated 14 Aug 2026
A hydrogen sulfide donor studied for its antioxidant potential and cellular protection
Best For Skin Types
All
Addresses
Usage Frequency
Daily
What Is Thiotaurine?
Thiotaurine is a sulphur-containing compound that acts as a hydrogen sulfide (H₂S) donor in skincare formulations. Hydrogen sulfide is a signalling molecule naturally present in the body, involved in various protective and regulatory functions at the cellular level.
In skincare, thiotaurine is primarily used for its antioxidant properties. It works to neutralise free radicals and oxidative stress—the unstable molecules that damage skin cells and contribute to visible ageing and inflammation.
Benefits for Your Skin
How It Works
Thiotaurine functions as a hydrogen sulfide donor, releasing H₂S molecules within the skin. Hydrogen sulfide modulates calcium channels and cellular signalling pathways, which influence how skin cells respond to oxidative stress and damage. By releasing H₂S, thiotaurine helps activate the skin's own protective processes.
The ingredient also works as a direct antioxidant, neutralising free radicals before they can oxidise skin lipids and proteins—a process that accelerates visible ageing and inflammation.
Clinical Evidence & References
Research has demonstrated that thiotaurine can inhibit oxidative damage in cultured skin cells exposed to environmental stressors such as cigarette smoke. Studies show it can suppress lipid peroxidation, a key pathway in skin ageing, and may activate cellular apoptosis pathways in damaged cells.
However, most available evidence comes from in vitro and animal studies. Clinical evidence in human skin remains limited, so its real-world efficacy in cosmetic formulations at typical concentrations is not yet fully characterised. Further research in human subjects would help establish its practical benefits in skincare.
How to Use
Thiotaurine is typically used as part of a broader antioxidant skincare routine. It works well alongside other protective ingredients such as vitamins C and E, and niacinamide. Apply as directed by the product instructions, usually once or twice daily. For best results, use consistently over several weeks, as antioxidant benefits build with regular use.
Safety & Precautions
Frequently Asked Questions
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Thymol Trimethoxycinnamate
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Tocopherol
Vitamin E antioxidant for skin protection
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