Humectant

Triisostearoyl 3-Glyceryl Ascorbate

INCI: TRIISOSTEAROYL 3-GLYCERYL ASCORBATE

Reviewed by Kate · Last updated 2 Jun 2026

A stable, oil-soluble form of vitamin C for sustained skin conditioning

Best For Skin Types

All, Dry, Mature, Combination

Addresses

Dryness, Hydration, Fine lines

Usage Frequency

Daily

What Is Triisostearoyl 3-Glyceryl Ascorbate?

Triisostearoyl 3-glyceryl ascorbate is a lipid-soluble derivative of vitamin C (ascorbic acid). It is created by chemically binding ascorbic acid to glycerol and isostearic acid, which makes it far more stable than pure vitamin C and allows it to penetrate through the skin's oily layers more effectively.

In skincare formulations, it functions as both a humectant and skin conditioner. Unlike water-soluble vitamin C, this form does not require a low pH to remain stable, making it easier to incorporate into a wider range of products without compromising stability or skin tolerance.

How It Works

The lipid-soluble structure of this ingredient allows it to dissolve in the oil phase of skin, potentially reaching deeper layers more readily than water-soluble vitamins. Once in the skin, it may be converted to active ascorbic acid, though the extent and speed of this conversion varies.

Its humectant function works by attracting water molecules to the outer layers of skin, while its conditioning properties create a smooth feel and support the skin barrier through light emollient action.

Clinical Evidence & References

Published clinical data specifically on this ingredient is limited. The stability and penetration advantages are established from a chemistry perspective, but research directly comparing its efficacy to other vitamin C derivatives in human skin studies is sparse.

As a vitamin C derivative, it theoretically shares antioxidant benefits with ascorbic acid, but actual efficacy in finished formulations depends on concentration, pH, and additional ingredients present. More research would strengthen claims about its specific benefits in skincare.

How to Use

This ingredient is typically found in serums, moisturisers, and treatment products. Apply to clean skin, either morning or evening, layering with other water-based products if needed. Since it is oil-soluble, it works well in lightweight oils or emulsified serums. Allow it to absorb fully before applying sunscreen or additional products. Patch test if your skin is sensitive to new formulations.

Safety & Precautions

Generally well-tolerated in skincare formulations. As a vitamin C derivative, sensitivity is uncommon, though some individuals may react to other formula ingredients.

Frequently Asked Questions

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