Antioxidant

Trisodium Ascorbyl Palmitate Phosphate

INCI: TRISODIUM ASCORBYL PALMITATE PHOSPHATE

Reviewed by Daisy · Last updated 20 Jul 2026

Also known as: Trisodium Ascorbyl Palmitate Phosphate

A stabilised vitamin C derivative that works as an antioxidant without the instability of pure ascorbic acid

Best For Skin Types

All, Oily, Combination, Mature

Addresses

Fine lines, Hyperpigmentation, Dullness

Usage Frequency

Daily

What Is Trisodium Ascorbyl Palmitate Phosphate?

Trisodium ascorbyl palmitate phosphate is a stabilised form of vitamin C, created by chemically bonding ascorbic acid with palmitic acid and phosphate groups. This modification makes it much more stable than pure vitamin C (ascorbic acid), which degrades quickly when exposed to air, light and water. The ingredient functions as an antioxidant in skincare formulations.

As a vitamin C derivative, it aims to deliver the benefits associated with vitamin C whilst being easier to formulate and longer-lasting in products. It is water-soluble and typically used in serums, essences and moisturisers.

How It Works

Trisodium ascorbyl palmitate phosphate is a prodrug, meaning it is inactive as applied but may be converted by skin enzymes into ascorbic acid (active vitamin C) once absorbed. This enzymatic conversion is theoretically what allows it to deliver vitamin C benefits.

As an antioxidant, vitamin C works by donating electrons to neutralise unstable free radical molecules, which can otherwise damage skin cells and contribute to signs of ageing. The stabilised structure of this derivative means the ingredient itself remains intact longer in the bottle, addressing a key limitation of pure ascorbic acid formulations.

Clinical Evidence & References

Evidence specific to trisodium ascorbyl palmitate phosphate is limited in published clinical literature. While vitamin C derivatives are widely used in skincare, robust human studies comparing this particular form to pure ascorbic acid or other derivatives are sparse.

Research on vitamin C and its derivatives more broadly suggests potential benefits for antioxidant protection and collagen support, but the bioavailability and efficacy of stabilised forms remains an area where further investigation would be valuable. Stability advantages are well-documented, but clinical outcomes specific to this derivative warrant more rigorous evaluation.

How to Use

This ingredient is typically used in serums or essences applied to clean skin in the morning or evening. Start with 2-3 times per week if you are new to vitamin C products, then increase frequency as tolerated. Layer it before heavier moisturisers. Avoid mixing with highly alkaline products or direct sunlight immediately after application, as vitamin C derivatives still benefit from stable storage conditions (cool, opaque containers away from light).

Safety & Precautions

Generally well-tolerated, though any vitamin C product can cause mild irritation, sensitivity or redness in some individuals, particularly those with very sensitive skin. Patch test before widespread use.

Frequently Asked Questions

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