Skin Conditioning

Vaccinium Myrtillus Leaf Cell Extract

INCI: VACCINIUM MYRTILLUS LEAF CELL EXTRACT

Reviewed by Kate · Last updated 14 Aug 2026

A plant extract rich in antioxidants that may help protect skin from environmental stress

Best For Skin Types

All

Addresses

Sensitivity, Redness

Usage Frequency

Daily

What Is Vaccinium Myrtillus Leaf Cell Extract?

Vaccinium myrtillus leaf cell extract is derived from bilberry leaves and contains a notable concentration of polyphenols and anthocyanins—naturally occurring compounds known for their antioxidant properties. This water-soluble extract is used in skincare as a skin conditioning agent, working to support the skin's natural defences against external stressors.

The extract functions primarily through its antioxidant content, which can help neutralise free radicals that accumulate on the skin's surface and within its layers. This mechanism underlies most of the observed skincare benefits associated with the ingredient.

How It Works

The extract works primarily through its polyphenol and anthocyanin content, which are powerful antioxidants. These compounds can neutralise free radicals—unstable molecules that accumulate in the skin due to sun exposure, pollution, and normal metabolic processes. By reducing oxidative stress at a cellular level, the extract may help prevent or slow some forms of skin damage.

Additionally, research suggests that anthocyanins specifically may help stabilise mast cells—immune cells that release inflammatory compounds during allergic or irritant reactions. This may explain preliminary findings around its soothing properties. The extract's ability to penetrate deeper skin layers when formulated in certain delivery systems (such as liposomes) may also enhance its effectiveness.

Clinical Evidence & References

In vitro studies using human keratinocyte cells show that Vaccinium myrtillus extract can reduce some markers of UV-induced damage when cells are pretreated before irradiation. However, these are laboratory findings and do not directly translate to proven benefits in living human skin under real-world conditions. The translation from cell studies to meaningful clinical benefit remains uncertain.

Animal studies indicate a potential anti-pruritic (itch-relieving) effect, particularly through the anthocyanin component, though this has not yet been extensively validated in human clinical trials. The ingredient's antioxidant capacity is well-established chemically, but evidence for tangible skincare benefits in human subjects remains limited. Further human studies would help clarify its practical value in topical formulations.

How to Use

This ingredient is typically found in serums, moisturisers, and treatment products at concentrations that vary by formulation. Use as directed on the product label, usually once or twice daily depending on the product type and your skin's tolerance. It works well alongside other antioxidants such as vitamin C or vitamin E, though this combination is not essential. As with any new skincare ingredient, introduce it gradually to monitor your skin's response.

Safety & Precautions

Vaccinium myrtillus extract is generally well-tolerated in topical skincare. Allergic reactions are rare but possible, particularly in those with sensitivities to berries or plant botanicals.

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Part of a family

Vaccinium Myrtillus Leaf Cell Extract is a variant of Vaccinium Myrtillus Fruit/Leaf Extract, the form you will most often see on an ingredients list.

A plant extract with astringent and antioxidant properties from bilberry fruit and leaves

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