Peptides

Ascorbyl Succinoyl Tetrapeptide-21

INCI: ASCORBYL SUCCINOYL TETRAPEPTIDE-21

Reviewed by Rosie · Last updated 2 Jun 2026

Also known as: Ascorbyl Succinoyl Tetrapeptide-21

A stabilised vitamin C derivative combined with peptide technology for antioxidant support

Best For Skin Types

All, Combination, Oily, Sensitive

Addresses

Antioxidant protection, Redness, Dullness, Environmental damage

Usage Frequency

Daily

What Is Ascorbyl Succinoyl Tetrapeptide-21?

Ascorbyl succinoyl tetrapeptide-21 is a hybrid ingredient that combines ascorbic acid (vitamin C) with a short-chain peptide. This combination creates a more stable form of vitamin C than pure ascorbic acid, which is prone to oxidation. The ingredient functions as an antioxidant, helping to neutralise free radicals generated by environmental stressors like UV exposure and pollution.

By pairing vitamin C with a tetrapeptide (a chain of four amino acids), this ingredient aims to deliver both antioxidant benefits and skin-conditioning properties. The peptide component may contribute to improved skin texture and firmness through its amino acid profile.

Benefits for Your Skin

How It Works

The ascorbyl succinoyl component donates electrons to neutralise free radicals, preventing them from damaging skin cells and collagen. This antioxidant action may help reduce visible signs of oxidative stress, including dullness and uneven tone.

The tetrapeptide portion works to condition and support skin barrier function. Peptides are recognised by the skin as building blocks and can signal improved firmness and elasticity. Together, the two components offer both protective and conditioning benefits in a single molecule.

Clinical Evidence & References

Published clinical studies specifically investigating ascorbyl succinoyl tetrapeptide-21 are limited. However, both components have established skincare credentials: vitamin C derivatives are well-documented for antioxidant efficacy, and peptides are recognised for their skin-conditioning and signalling properties.

The combination is designed to improve upon pure vitamin C stability while retaining antioxidant benefits, making it a pragmatic choice for formulations where stability is a concern. More targeted research would help clarify its specific efficacy and optimal concentration range.

How to Use

This ingredient is typically found in serums and treatment products. It works well in routines alongside other antioxidants, though layering multiple vitamin C derivatives is unnecessary. Apply to clean skin before moisturiser. If your skin is sensitive or prone to irritation, introduce gradually and monitor tolerance. Vitamin C derivatives are generally better tolerated than pure ascorbic acid, but individual responses vary.

Safety & Precautions

Generally well-tolerated across most skin types. As with all vitamin C derivatives, discontinue if irritation or sensitivity develops. Not recommended during pregnancy without consulting a healthcare provider.

If you’re pregnant or breastfeeding, please check with us first — [email protected].

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