Argireline
INCI: Acetyl Hexapeptide-8
Reviewed by Rosie · Last updated 18 Aug 2026
Also known as: Acetyl Hexapeptide-3, Acetyl Hexapeptide-8
The expression line relaxer
Best For Skin Types
All skin types
Addresses
Effective Concentrations
5-10%
Usage Frequency
As directed on product packaging
EWG Safety Score
What Is Argireline?
Argireline (acetyl hexapeptide-3 or acetyl hexapeptide-8) is a synthetic peptide designed to reduce the appearance of expression lines and wrinkles. Often referred to as topical Botox, it works by relaxing facial muscle contractions without the need for injections.
Argireline interferes with the SNARE complex, which is essential for muscle contraction. By inhibiting this complex, it reduces the intensity of facial muscle movements that cause dynamic wrinkles, particularly around the forehead and eyes.
While Argireline is not as powerful as Botox injections, clinical studies have shown it can reduce wrinkle depth by up to 30% with consistent use over 30 days. It works best on expression lines caused by repeated facial movements.
Argireline is most effective at concentrations of 5-10% and works well when combined with other peptides and hydrating ingredients. Apply to areas prone to expression lines.
Clinical Evidence & References
Argireline is a synthetic peptide that works by inhibiting the SNARE complex, thereby reducing the intensity of facial muscle contractions responsible for dynamic wrinkles. Clinical evidence supporting its efficacy is reasonably well established, though not extensive. Published studies demonstrate that consistent use at concentrations of 5–10% can reduce wrinkle depth by approximately 30% over 30 days, with greatest benefit for expression lines on the forehead and around the eyes.
However, the evidence base shows notable limitations. Available studies tend to be relatively small and short-term, and results vary considerably between individuals. Argireline is considerably less potent than injectable botulinum toxin, and benefits require sustained application over weeks rather than days. Tolerance to the ingredient may develop with prolonged use, though this warrants further investigation. Currently available evidence supports modest efficacy for reducing the appearance of dynamic wrinkles, but long-term data and larger comparative trials remain limited.
Published Research
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Argireline: an antiwrinkle peptide International Journal of Cosmetic Science, 2002
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Anti-aging efficacy of acetyl hexapeptide-8 (Argireline) Journal of Cosmetic and Laser Therapy, 2013
How to Use
Safety & Precautions
Frequently Asked Questions
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Argireline is a variant of Acetyl Hexapeptide-8, the form you will most often see on an ingredients list.
AKA agireline and acetyl hexpeptide-3 Has water-binding abilities
Related Ingredients
Acetyl Hexapeptide-8
AKA agireline and acetyl hexpeptide-3 Has water-binding abilities
Pentapeptide-18
Neuromodulating peptide for expression line reduction
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A peptide-derived antioxidant that helps protect skin from oxidative stress
Anacardoyl Sh-Pentapeptide-39 Tripeptide-1
A peptide complex designed to support skin resilience and collagen production
Arginine/Lysine Polypeptide
A peptide blend that supports skin structure and hydration
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A peptide blend from citrus extracts that conditions and supports skin texture
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