Acetyl Hexapeptide-8
INCI: Argireline
Reviewed by Emma · Last updated 18 Aug 2026
Also known as: Argireline, acetyl hexapeptide-3, acetyl hexapeptide-8 amide
AKA agireline and acetyl hexpeptide-3 Has water-binding abilities
Best For Skin Types
All skin types
Usage Frequency
As directed on product packaging
EWG Safety Score
What Is Acetyl Hexapeptide-8?
Acetyl hexapeptide-8 is a synthetic peptide that is primarily used in skin care products. Formerly known by its original trade name Argireline and generically as acetyl hexapeptide-3, it has water-binding properties and skin-restoring abilities that play roles in helping skin look and feel younger.
Acetyl hexapeptide-8 is a neurotransmitter-inhibiting peptide, meaning it works within skin’s surface layers to interrupt the look of expression lines; however, its efficacy in this regard doesn’t replace in-office wrinkle-smoothing injectable procedures.
Interestingly, research from suppliers has shown this peptide also helps support skin’s collagen and preserve a firmer appearance.
Studies have shown this peptide can penetrate further into skin and delivery greater efficacy for smoothing expression lines if specific formulary steps are followed, including accounting for the type of emulsion (a higher water content allows greater penetration). As always, this demonstrates the importance of selecting well-formulated skin care products to add to your routine.
Acetyl hexapeptide-8 may also be referred to as acetyl hexapeptide-8 amide.
Some brands’ marketing claim that acetyl hexapeptide-8 is “botox in a jar,” but this just isn’t true.
Benefits for Your Skin
Clinical Evidence & References
- Cosmetic Ingredient Review, April 2021, pages 1-12
- Cosmetics, November 2020, Issue 7, Volume 4, page 91
- La Clinica Terapeutica, November 2020, pages e539-e548
- Cutaneous and Ocular Toxicology, March 2015, pages 46-52
- European Journal of Pharmaceutical Sciences, February 2015, pages 27-35
- Dermatologic Therapy, September-October 2007, issue 5, pages 343-349
Published Research
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Argireline decreases the expression of neuronal exocytosis complex International Journal of Cosmetic Science, 2002
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Clinical efficacy of acetyl hexapeptide-8 in facial wrinkles Journal of Cosmetic and Laser Therapy, 2013
Frequently Asked Questions
From the Clinic
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Take the skin quizOther forms of Acetyl Hexapeptide-8
These appear on ingredients lists under different names but are the same substance. Acetyl Hexapeptide-8 is the common form.
Related Ingredients
Argireline
The expression line relaxer
Pentapeptide-18
Neuromodulating peptide for expression line reduction
Acetyl Hexapeptide-7
A peptide designed to support skin's protective function and resilience
Acetyl Hexapeptide-71 Amide
A peptide that conditions skin and may support firmness when used consistently
Acetyl Hexapeptide-76 Amide
A peptide that conditions skin and may support a smoother appearance
Acetyl Hexapeptide-8 Amide
A peptide that conditions skin and may help minimise the appearance of fine lines
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