Pentapeptide-18
INCI: acetyl hexapeptide-8
Reviewed by Daisy · Last updated 18 Aug 2026
Also known as: acetyl hexapeptide-3, agireline
Neuromodulating peptide for expression line reduction
Addresses
EWG Safety Score
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What Is Pentapeptide-18?
Pentapeptide-18, also known as Leuphasyl, is a neurotransmitter-affecting peptide that works by mimicking the activity of enkephalins. It reduces the release of neurotransmitters at the neuromuscular junction, helping to relax facial muscles and diminish expression lines.
Unlike Botox which blocks neurotransmitters, this peptide modulates their release, offering a gentler approach to reducing dynamic wrinkles. It works synergistically with other neuromuscular peptides like Argireline.
Benefits for Your Skin
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Pentapeptide-18 is a variant of Acetyl Hexapeptide-8, the form you will most often see on an ingredients list.
AKA agireline and acetyl hexpeptide-3 Has water-binding abilities
Related Ingredients
Acetyl Hexapeptide-8
AKA agireline and acetyl hexpeptide-3 Has water-binding abilities
Argireline
The expression line relaxer
Pentapeptide-15
A peptide designed to support skin's structural integrity and resilience
Pentapeptide-16
A peptide fragment that supports skin conditioning and structural integrity
Pentapeptide-17
A peptide that conditions skin and may support structural integrity
Pentapeptide-2
A humectant peptide that draws moisture into the skin
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