Pentapeptide-2

Pentapeptide-2 is a short-chain peptide — a fragment of amino acids — designed to function as a humectant in skincare formulations. Humectants work by attracting water molecules from the environment and deeper skin layers, binding them to the outer surface to improve hydration levels.This ingredient is commonly incorporated into serums, moisturisers and hydrating treatments where increased water retention is the goal.

Pentapeptide-2 operates as a humectant by binding water molecules through its molecular structure, which contains hygroscopic properties. This allows it to draw moisture from the air and from deeper dermal layers, delivering it to the epidermis where it can improve skin hydration and feel.Unlike occlusive ingredients that seal moisture in, humectants work by actively attracting and holding water, making them particularly useful in climates with adequate humidity.

Pentapeptide-2 works best when applied to damp skin, as humectants are most effective when there is moisture available to draw in. Layer it under an occlusive moisturiser or facial oil in dry climates to lock in the hydration it provides. It can typically be used daily as part of your hydrating routine.

Pentapeptide-2 is generally well-tolerated and suitable for most skin types, including sensitive skin. Peptides are rarely allergenic, though patch testing is always recommended before full application.