Caffeoyl Tripeptide-35

Caffeoyl tripeptide-35 is a synthetic peptide compound derived from caffeic acid, a naturally occurring polyphenol found in plants. It combines a caffeoyl group (from caffeic acid) with a short chain of three amino acids, creating a molecule designed to deliver antioxidant benefits to the skin.In skincare formulations, this ingredient functions primarily as an antioxidant and skin protectant. It also has chelating properties, meaning it can bind to metal ions that may otherwise generate free radicals. Some formulations incorporate it for its UV-protective potential, though this is typically…

The ingredient works by donating electrons to neutralise free radicals—unstable molecules that damage skin cells and collagen. The caffeic acid component is responsible for most of this antioxidant activity. Additionally, the peptide structure allows the molecule to interact with skin proteins in ways that support barrier function and resilience.The chelating function means it can capture metal ions (such as iron or copper) that would otherwise catalyse the formation of new free radicals. Some research suggests related caffeoyl compounds may inhibit tyrosinase, an enzyme involved in melanin…

This ingredient is typically found in serums, moisturisers, and protective day creams at lower concentrations, where it works synergistically with other antioxidants and UV filters. For optimal benefit, use it as part of a broader skincare routine that includes sunscreen, as external protection remains the most effective defence against the environmental stressors this ingredient addresses. It can be used daily without concern for tolerance issues in most cases.

Caffeoyl tripeptide-35 is generally well-tolerated and not known to cause irritation or sensitisation at typical cosmetic concentrations. As with all peptide ingredients, it is unlikely to penetrate into systemic circulation when applied topically.