Peptides

Caffeoyl Tripeptide-34

INCI: CAFFEOYL TRIPEPTIDE-34

Reviewed by Daisy · Last updated 2 Jun 2026

Also known as: Caffeoyl Tripeptide-34

A peptide derivative with potential to support skin conditioning and pigmentation control

Best For Skin Types

All

Addresses

Hyperpigmentation, Uneven skin tone

Usage Frequency

Daily

What Is Caffeoyl Tripeptide-34?

Caffeoyl Tripeptide-34 is a synthetic peptide—a short chain of amino acids—combined with caffeic acid, a naturally occurring compound found in plants. It functions as a skin conditioning agent designed to support the skin's appearance and texture.

This ingredient belongs to the broader category of peptides used in skincare, which work by interacting with skin cells to influence their behaviour and support various skin functions.

How It Works

Caffeoyl Tripeptide-34 combines a short peptide chain with caffeic acid, a compound known to interact with enzymes involved in melanin production. Research into related caffeoyl compounds suggests they may inhibit tyrosinase activity—an enzyme central to melanin synthesis—potentially supporting a more even skin tone.

As a peptide, it may also communicate with skin cells to support their natural conditioning and maintenance functions, though the specific mechanism for this particular tripeptide requires further research.

Clinical Evidence & References

Evidence for Caffeoyl Tripeptide-34 specifically is limited. However, research into caffeoyl compounds (the chemical component of this ingredient) shows they can inhibit tyrosinase activity in laboratory studies, suggesting potential relevance to pigmentation control.

Broader research on peptides in cosmetics indicates they are generally well-tolerated and safe for topical use. More targeted clinical studies on this particular ingredient would help clarify its efficacy in real-world skincare applications.

How to Use

This ingredient is typically found in serums, creams, and targeted treatments. Use as directed on the product label, usually once or twice daily. It can generally be layered with other actives, though starting with one new ingredient at a time helps you assess tolerance.

Safety & Precautions

Peptides are generally well-tolerated in cosmetic formulations. As with any new skincare ingredient, patch test if you have sensitive skin.

Frequently Asked Questions

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