Peptides

Caffeoyl Sh-Heptapeptide-13

INCI: CAFFEOYL SH-HEPTAPEPTIDE-13

Reviewed by Emma · Last updated 2 Jun 2026

Also known as: Caffeoyl Sh-heptapeptide-13

A peptide-based antioxidant designed to support skin protection and resilience

Best For Skin Types

All

Addresses

Oxidative stress, Barrier repair, Sensitivity

Usage Frequency

Daily

What Is Caffeoyl Sh-Heptapeptide-13?

Caffeoyl Sh-Heptapeptide-13 is a synthetic peptide that combines a caffeic acid moiety (derived from natural sources like coffee and polyphenol-rich plants) with a seven-amino acid peptide chain. Peptides are short chains of amino acids that can penetrate the skin's outer layers and communicate with skin cells to trigger specific responses.

This ingredient functions as an antioxidant and skin protectant, working to neutralise free radicals and support the skin's natural defence mechanisms against environmental stress.

Benefits for Your Skin

How It Works

The caffeic acid component provides direct antioxidant activity by donating electrons to unstable free radicals, effectively neutralising them before they can damage skin cells. This helps prevent oxidative stress, which accelerates visible signs of ageing and weakens skin barrier function.

The peptide chain allows this active compound to penetrate more effectively into the skin and may also trigger cellular signalling pathways that enhance the skin's own protective mechanisms.

Clinical Evidence & References

Research into peptide safety in cosmetics indicates that caffeoyl-peptide compounds are generally well-tolerated and can be safely incorporated into skincare formulations. Caffeic acid itself has demonstrated tyrosinase-inhibiting properties in laboratory studies, which suggests potential benefits for even skin tone, though dedicated human studies on this specific peptide are limited.

The evidence supports its use as an antioxidant protective ingredient, though further clinical research in human subjects would strengthen confidence in specific efficacy claims for visible skin outcomes.

How to Use

Caffeoyl Sh-Heptapeptide-13 is typically found in serums, moisturisers, and targeted treatments. It pairs well with other antioxidants (such as vitamin C or niacinamide) and can be used daily as part of a morning or evening routine. Apply to clean skin before moisturiser for optimal absorption.

Safety & Precautions

Generally well-tolerated in cosmetic formulations. As with all peptides, patch testing is recommended for those with sensitive skin, particularly if using multiple active ingredients.

Frequently Asked Questions

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