Peptides

Caffeoyl Sh-Decapeptide-9

INCI: CAFFEOYL SH-DECAPEPTIDE-9

Reviewed by Emma · Last updated 2 Jun 2026

Also known as: Caffeoyl Sh-decapeptide-9

A peptide-derived ingredient that conditions skin and may support even skin tone

Best For Skin Types

All, Mature, Sensitive

Addresses

Hyperpigmentation, Hydration, Dryness

Usage Frequency

Daily

What Is Caffeoyl Sh-Decapeptide-9?

Caffeoyl SH-Decapeptide-9 is a peptide — a short chain of amino acids — derived from caffeic acid, a naturally occurring compound found in plants. In skincare formulations, it functions primarily as a skin conditioning agent, helping to improve the texture and feel of the skin.

Peptides like this one are used in cosmetics because they are perceived as having a favourable safety profile and can be designed to target specific skin concerns. This particular peptide combines a caffeic acid moiety with a decapeptide backbone, potentially offering both moisturising and antioxidant properties.

How It Works

The ingredient works through two main pathways. First, as a peptide-based humectant, it can draw moisture into the stratum corneum and support skin hydration. Second, the caffeic acid component is believed to offer antioxidant benefits, which may help mitigate oxidative stress in the skin.

Preliminary research suggests that caffeic acid derivatives may interact with tyrosinase, an enzyme involved in melanin production. However, this mechanism has not been extensively studied for this specific peptide, and its practical efficacy in this regard requires further investigation.

Clinical Evidence & References

Limited clinical data exists specifically for Caffeoyl SH-Decapeptide-9. However, caffeic acid and related compounds have shown promise in laboratory studies for tyrosinase inhibition, which is relevant to melanin regulation. Peptides as a class are generally recognised as safe in cosmetics and are increasingly studied using modern risk assessment frameworks.

To date, no major clinical trials have directly assessed this ingredient's efficacy in human subjects. Most evidence comes from in vitro (laboratory) studies of structurally related compounds, so claims about skin tone evening should be considered provisional rather than definitive.

How to Use

This ingredient is typically found in serums, moisturisers, and targeted treatments. Use as directed by the product formulation — usually once or twice daily. It can be layered with other active ingredients, though it is sensible to introduce peptide-rich products gradually if your skin is reactive. Allow several weeks of consistent use to assess any benefits to skin texture or appearance.

Safety & Precautions

Peptides are generally well-tolerated in cosmetic formulations. Caffeoyl SH-Decapeptide-9 has no widely documented contraindications, though those with known sensitivities to peptides or caffeic acid should patch-test first.

Frequently Asked Questions

From the Clinic

Not sure what your skin actually needs?

Two minutes, a few questions, and we’ll point you at what matters — no guesswork.

Take the skin quiz

Learn More About Skincare Ingredients

Explore our comprehensive ingredient glossary to understand what's in your products.

Browse All Ingredients

Authorised Stockist

Official UK retailer

Tracked Delivery

Free UK shipping over £50

5 Star Rating

Trusted by thousands

Expert Advice

Free consultations