Peptides

Caffeoyl Pentapeptide-20

INCI: CAFFEOYL PENTAPEPTIDE-20

Reviewed by Rosie · Last updated 2 Jun 2026

Also known as: Caffeoyl Pentapeptide-20

A peptide-derived antioxidant that helps protect skin from environmental stress

Best For Skin Types

All

Addresses

Environmental damage, Oxidative stress

Usage Frequency

Daily

What Is Caffeoyl Pentapeptide-20?

Caffeoyl Pentapeptide-20 is a synthetic peptide—a short chain of amino acids—combined with caffeic acid, a naturally occurring antioxidant compound. It's designed to deliver antioxidant benefits whilst also providing conditioning properties to skin and hair.

As an antioxidant, this ingredient works to neutralise free radicals and reduce oxidative stress on the skin, which can be caused by UV exposure, pollution, and other environmental factors.

Benefits for Your Skin

How It Works

The caffeoyl component—derived from caffeic acid—is a polyphenol known for its antioxidant capacity. When combined with a pentapeptide (five amino acids), the ingredient can help neutralise free radicals that accumulate from sun exposure, pollution, and oxidative stress. This reduces the risk of oxidative damage to skin cells and collagen.

The peptide element also acts as a skin conditioning agent, helping to improve the texture and feel of the skin.

Clinical Evidence & References

Research on caffeoyl compounds demonstrates antioxidant activity and potential effects on melanin synthesis through tyrosinase inhibition, though studies on this specific peptide formulation in human skin remain limited. The safety evaluation of peptides in cosmetics has been established through modern risk assessment frameworks, and peptide ingredients are generally considered well-tolerated in topical formulations.

More targeted clinical studies on Caffeoyl Pentapeptide-20 would help clarify its efficacy at typical cosmetic concentrations and any measurable benefits to skin appearance or barrier function over time.

How to Use

This ingredient is typically found in serums, moisturisers, and treatment products. As with most antioxidants, it works best as part of a consistent skincare routine and is particularly useful in morning formulations to help protect skin during the day when environmental exposure is highest.

Safety & Precautions

Peptides in cosmetics are considered safe when properly formulated. Caffeoyl Pentapeptide-20 has not been associated with significant irritation or sensitisation in typical cosmetic use.

Frequently Asked Questions

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