Best For Skin Types
All
Addresses
Usage Frequency
Daily
What Is Caffeoyl Pentapeptide-20?
Caffeoyl Pentapeptide-20 is a synthetic peptide—a short chain of amino acids—combined with caffeic acid, a naturally occurring antioxidant compound. It's designed to deliver antioxidant benefits whilst also providing conditioning properties to skin and hair.
As an antioxidant, this ingredient works to neutralise free radicals and reduce oxidative stress on the skin, which can be caused by UV exposure, pollution, and other environmental factors.
Benefits for Your Skin
How It Works
The caffeoyl component—derived from caffeic acid—is a polyphenol known for its antioxidant capacity. When combined with a pentapeptide (five amino acids), the ingredient can help neutralise free radicals that accumulate from sun exposure, pollution, and oxidative stress. This reduces the risk of oxidative damage to skin cells and collagen.
The peptide element also acts as a skin conditioning agent, helping to improve the texture and feel of the skin.
Clinical Evidence & References
Research on caffeoyl compounds demonstrates antioxidant activity and potential effects on melanin synthesis through tyrosinase inhibition, though studies on this specific peptide formulation in human skin remain limited. The safety evaluation of peptides in cosmetics has been established through modern risk assessment frameworks, and peptide ingredients are generally considered well-tolerated in topical formulations.
More targeted clinical studies on Caffeoyl Pentapeptide-20 would help clarify its efficacy at typical cosmetic concentrations and any measurable benefits to skin appearance or barrier function over time.
How to Use
This ingredient is typically found in serums, moisturisers, and treatment products. As with most antioxidants, it works best as part of a consistent skincare routine and is particularly useful in morning formulations to help protect skin during the day when environmental exposure is highest.
Safety & Precautions
Frequently Asked Questions
From the Clinic
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Caffeine Carboxyloyl Sh-Decapeptide-1
A peptide derivative combining caffeine with a decapeptide chain for skin conditioning
Caffeine Carboxyloyl Tripeptide-37
A peptide derivative combining caffeine and amino acids for skin conditioning
Caffeoyl Hexapeptide-65
A peptide derivative with antioxidant and purifying properties for skin conditioning
Caffeoyl Pentapeptide-4
A peptide derivative that supports skin conditioning and structural integrity
Caffeoyl Sh-Decapeptide-9
A peptide-derived ingredient that conditions skin and may support even skin tone
Caffeoyl Sh-Heptapeptide-13
A peptide-based antioxidant designed to support skin protection and resilience
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