Humectant

Cannabis Sativa Seed/Stem Oil

INCI: CANNABIS SATIVA SEED/STEM OIL

Reviewed by Rosie · Last updated 14 Aug 2026

Also known as: Cannabis Sativa Seed/stem Oil

A plant-derived oil that conditions and hydrates the skin barrier

Best For Skin Types

All, Dry, Sensitive, Combination

Addresses

Dryness, Barrier repair, Hydration, Sensitivity

Usage Frequency

Daily

What Is Cannabis Sativa Seed/Stem Oil?

Cannabis sativa seed and stem oil is derived from the cannabis plant, but contains little to no THC or CBD—the psychoactive and therapeutic compounds associated with cannabis. Instead, it is rich in fatty acids, including linoleic acid and oleic acid, along with natural plant sterols and minor bioactive compounds.

In skincare formulations, it functions as both an emollient and humectant, meaning it can soften the skin surface and help support moisture retention. It is typically incorporated into creams, serums, and balms at modest concentrations.

How It Works

The oil works through its fatty acid content, particularly linoleic and oleic acids, which mimic the natural lipids found in the skin's stratum corneum. When applied topically, these fatty acids integrate into the skin barrier, helping to fill gaps and reduce transepidermal water loss (TEWL).

Additionally, the oil's humectant properties allow it to attract and bind water molecules from the environment and deeper skin layers, delivering hydration to the outer layers of skin. This dual action—barrier repair and moisture attraction—makes it a multi-functional conditioning ingredient.

Clinical Evidence & References

Direct clinical studies on cannabis sativa seed and stem oil as a standalone skincare ingredient are limited. However, the fatty acid profile is well-documented in dermatological literature, and linoleic acid in particular is known to support barrier function and reduce inflammation in compromised skin.

Most evidence for this ingredient comes from historical use, consumer tolerance data, and general knowledge of plant-derived fatty acids rather than rigorous clinical trials. It is generally regarded as safe and well-tolerated, though more targeted research would help clarify its specific efficacy for particular skin concerns.

How to Use

Cannabis sativa seed oil works well in formulations designed for hydration and barrier repair. It can be used daily as part of a moisturiser or layered under richer creams if skin is very dry. Because it is an oil, a little goes a long way—start with a small amount and build up if needed. It pairs well with other hydrating or barrier-supporting ingredients like ceramides, glycerin, or hyaluronic acid.

Safety & Precautions

Generally well-tolerated and suitable for most skin types, including sensitive skin. Patch test if you have known sensitivities to plant oils. Not psychoactive.

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