Croton Lechleri Sap Extract
INCI: CROTON LECHLERI SAP EXTRACT
Reviewed by Kate · Last updated 2 Jun 2026
Amazonian plant sap with traditional use and emerging evidence for skin conditioning
Best For Skin Types
All, Sensitive
Addresses
Usage Frequency
Daily
What Is Croton Lechleri Sap Extract?
Croton Lechleri Sap Extract, commonly known as Dragon's Blood, is a bright red resin collected from the Croton lechleri tree native to South American rainforests. The sap contains a complex mixture of phytochemicals—including phenolic compounds and other bioactive molecules—that have been used in traditional medicine for centuries.
In skincare formulations, it functions as a skin conditioning agent. The extract's chemistry suggests multiple biological pathways of interest, though its application in dermatology remains relatively underexplored in clinical settings compared to other established ingredients.
How It Works
The extract appears to work through multiple mechanisms. Research indicates it may inhibit the release of substance P, a neuropeptide involved in neurogenic inflammation—a type of inflammatory response triggered by nerve signals. This could theoretically help calm reactive or sensitised skin.
The phytochemicals present also demonstrate antioxidant and antimicrobial activity in laboratory settings, though the concentration and bioavailability of these compounds in topical formulations requires further investigation to understand their practical impact on skin.
Clinical Evidence & References
Preclinical studies show promise across several pathways: anti-inflammatory, antioxidant, antimicrobial, and antifungal activity have all been observed in controlled laboratory conditions. Clinical evidence for wound healing and antiviral properties exists, though the dermatological research base remains limited.
Research specifically examining neurogenic inflammation suggests the extract may reduce substance P release in a meaningful, dose-dependent manner. However, most evidence comes from in vitro (laboratory) studies or traditional use; robust clinical trials in dermatology are sparse. Further investigation is needed to establish clearer efficacy and optimal concentrations for skincare applications.
How to Use
Dragon's Blood extract is typically found in serums, creams, and balms at modest concentrations. There is no standard optimal concentration established in the literature. Use as directed on the product label, and allow several weeks of consistent use to assess any changes in skin appearance or feel.
Safety & Precautions
Frequently Asked Questions
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