Crystallins

Crystallins are a group of proteins naturally found in various tissues, including the eye lens, skin, heart and skeletal muscle. In skincare, they function as conditioning agents that help support the skin's structural integrity and moisture retention.These proteins belong to two main families: alpha-crystallins and beta-gamma-crystallins. Alpha-crystallins in particular have been studied for their chaperone-like properties, which may help protect proteins within skin cells from damage and aggregation.

Crystallins work primarily through their conditioning properties, helping to seal in moisture and strengthen the skin's protective barrier. When applied topically, they interact with the outer layers of skin to improve hydration and reduce water loss.Alpha-crystallins, in particular, exhibit chaperone-like behaviour—a property borrowed from their stress-response function in other tissues. This means they may help stabilise other proteins in the skin and reduce damage from environmental stressors, though more research is needed to fully understand this mechanism in a skincare context.

Crystallins are typically incorporated into serums, moisturisers and conditioning treatments. They work well alongside other hydrating and barrier-supporting ingredients such as ceramides and fatty acids. Use as directed on product packaging, usually as part of your regular skincare routine.

Crystallins are generally well-tolerated and derived from natural sources. They are unlikely to cause irritation in most individuals, though those with known sensitivities to protein-based ingredients should patch-test first.