Decacarboxymethyl Palmitoyl Pentapeptide-67

Decacarboxymethyl palmitoyl pentapeptide-67 is a synthetic peptide conjugate — a short chain of amino acids combined with a fatty acid (palmitic acid). It functions as a humectant, meaning it draws moisture into the skin, whilst also offering conditioning and protective benefits to the skin barrier.This ingredient is used in skincare formulations at relatively modest concentrations to support the skin's natural hydration mechanisms and help maintain skin integrity, particularly in products targeted towards sensitive or reactive skin.

As a humectant, this peptide works by attracting and binding water molecules to the outer layers of skin, helping to maintain hydration levels throughout the day. The peptide structure may also interact with skin cells to reinforce the barrier function — the protective layer that prevents water loss and defends against irritants.The palmitoyl component (fatty acid attachment) helps the ingredient integrate into the skin's lipid matrix, potentially enhancing its conditioning and protective effects.

This ingredient is typically found in serums, moisturisers and barrier repair products. Use as directed on the product label — usually once or twice daily as part of your regular skincare routine. It can generally be combined with other hydrating or active ingredients, though if your skin is very reactive, introduce new products one at a time.

Generally well-tolerated in skincare formulations. As with any ingredient, discontinue use if irritation occurs, and perform a patch test if you have known sensitivities to peptides or fatty acid derivatives.