Peptides

Cyanocobalamin/Yeast Polypeptide

INCI: CYANOCOBALAMIN/YEAST POLYPEPTIDE

Reviewed by Emma · Last updated 14 Aug 2026

Also known as: Cyanocobalamin/yeast Polypeptide

A peptide and vitamin B12 combination that conditions and supports skin's structural integrity

Best For Skin Types

All, Dry, Sensitive, Mature

Addresses

Dryness, Hydration, Barrier repair

Usage Frequency

Daily

What Is Cyanocobalamin/Yeast Polypeptide?

Cyanocobalamin/Yeast Polypeptide is a hybrid ingredient combining cyanocobalamin (vitamin B12) with polypeptides derived from yeast. Yeast polypeptides are short-chain amino acid sequences that mimic some of the conditioning properties of larger proteins, whilst cyanocobalamin contributes B vitamin activity known to support skin health.

This combination is primarily used as a skin conditioning agent, working to improve the appearance and feel of the skin surface.

How It Works

Yeast polypeptides work primarily as humectants and film-formers—they absorb water and create a light protective layer on the skin surface, which helps lock in moisture and improve tactile smoothness. Cyanocobalamin adds antioxidant support and may help support skin's natural metabolic processes.

Together, these components work to condition the skin rather than actively transform it, making this a supportive rather than active treatment ingredient.

Clinical Evidence & References

Evidence specifically addressing this combination is limited. Yeast polypeptides have a history of use in cosmetics as conditioning agents, and some research suggests peptides generally can improve skin hydration and elasticity when used consistently. Cyanocobalamin's role in skincare is less well-established than its systemic health benefits.

This ingredient is best viewed as a conditioning and supportive addition to a routine rather than a targeted treatment for specific concerns. More robust clinical data would help clarify its measurable benefits.

How to Use

This ingredient is typically incorporated into serums, moisturisers and treatments where it can remain in contact with the skin. Use as directed by the product formulation. It pairs well with other conditioning and hydrating ingredients. No specific application technique is required beyond standard product use.

Safety & Precautions

Generally well-tolerated across skin types. Allergic reactions are rare but possible, particularly in those with yeast sensitivities. Patch test if you have a known sensitivity to yeast-derived ingredients.

Frequently Asked Questions

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