Decyloxazolidinone
INCI: DERMAC SR-38
Reviewed by Daisy · Last updated 14 Aug 2026
Also known as: DERMAC SR-38
Functions as a preservative
EWG Safety Score
What Is Decyloxazolidinone?
Decyloxazolidinone belongs to a class of synthetic protein synthesis inhibitors known as oxazolidinones. Their primary function in cosmetics is to serve as preservatives thanks to their antimicrobial properties.\n\nIn addition to this function, decyloxazolidinone is also an effective skin conditioning ingredient. That’s because it’s designed to mimic ceramides in skin’s surface layers, technically known as the stratum corneum.\n\nIt is considered non-irritating in concentrations as high as 10%, far above its usual usage in cosmetics products. It is also used as a penetration enhancer.\n\nIn its raw form, decyloxazolidinone is a white, crystalline, odorless solid. It is also commonly referred to by its trade name, DERMAC SR-38.
Clinical Evidence & References
Published Research
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CoSmileEurope, Website, Accessed July 2025 CoSmileEurope, 2025
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Macedonian Pharmaceutical Bulletin, December 2022, pages 285-285 Macedonian Pharmaceutical Bulletin, 2022
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Dermatology Online Journal, January 2010, ePublication Dermatology Online Journal, 2010
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Songkanakarin Journal of Science and Technology, May-June 2009, pages 299-321 Songkanakarin Journal of Science and Technology, 2009
From the Clinic
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