Preservative

Diazolidinyl Urea

INCI: DIAZOLIDINYL UREA

Reviewed by Emma · Last updated 14 Aug 2026

Also known as: Diazolidinyl Urea

A broad-spectrum preservative that extends the shelf life of skincare formulations

Best For Skin Types

All

Effective Concentrations

0.05–0.6%

What Is Diazolidinyl Urea?

Diazolidinyl urea is a synthetic preservative commonly used in skincare and cosmetic products to prevent microbial growth and extend product shelf life. It belongs to a class of formaldehyde-releasing preservatives, meaning it gradually releases small amounts of formaldehyde during storage—a mechanism that contributes to its antimicrobial effectiveness.

The ingredient functions by inhibiting the growth of bacteria, fungi and other microorganisms that could otherwise compromise product safety and integrity. It is used in relatively low concentrations, typically around 0.05% to 0.6%, and is found in roughly 0.5% of skincare products on the market.

How It Works

Diazolidinyl urea works by releasing formaldehyde at a controlled rate within the product, which inhibits microbial growth. This mechanism is effective across a broad spectrum of bacteria and fungi, making it a versatile preservative choice for formulators. The antimicrobial activity remains effective even at lower concentrations, which is why it can be used sparingly.

Clinical Evidence & References

Research indicates that diazolidinyl urea is an effective preservative at concentrations as low as 0.05%, and microbial challenge testing has confirmed its antimicrobial activity across all tested concentrations. However, as with all formaldehyde-releasing preservatives, there is evidence that some individuals may develop contact sensitivity to the ingredient, with studies reporting sensitization rates of around 0.54% in patch-tested populations.

It is important to note that sensitivity reactions in some individuals appear to be attributable to the formaldehyde released by the ingredient rather than diazolidinyl urea itself. For individuals without known sensitivity, the preservative is generally considered safe when used within established concentration limits.

How to Use

Diazolidinyl urea is a preservative system rather than an active skincare ingredient, so there are no specific application instructions for consumers. Its role is purely functional—to protect the product in the bottle. If you have a known sensitivity to formaldehyde or formaldehyde releasers, check product labels and consider patch testing before regular use, or opt for products preserved with alternative systems.

Safety & Precautions

Diazolidinyl urea is generally well-tolerated and considered safe within approved concentration limits. However, individuals with known contact sensitivity to formaldehyde or formaldehyde-releasing preservatives may experience irritation or allergic contact dermatitis.

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