Glycylglycine

Glycylglycine oleamide (GGO) is a modified amino acid compound created by combining glycylglycine—the simplest dipeptide—with oleic acid. It functions as a skin-conditioning agent designed to help preserve the structural integrity of skin proteins, particularly collagen and elastin, which naturally deteriorate over time.The ingredient works by targeting glycation, a chemical process where sugars bind to proteins in the skin. This process accelerates with age and sun exposure, contributing to visible signs of ageing such as loss of elasticity and wrinkle formation.

Glycylglycine oleamide appears to work through two main mechanisms. First, it inhibits glycation—the non-enzymatic reaction between sugars and proteins that creates cross-links and stiffens skin tissue. By reducing this process, it helps preserve the natural flexibility and appearance of collagen and elastin fibres.Second, research suggests GGO may help regulate the activity of elastase (MMP-12), an enzyme that breaks down elastin over time. By moderating this enzyme's activity, the ingredient may help slow the natural degradation of skin's elastic fibres that occurs with age.

Glycylglycine oleamide is typically incorporated into serums, creams, and moisturisers at low to moderate concentrations. It works well alongside other age-support ingredients such as retinoids and antioxidants. There is no specific guidance on frequency, though products containing this ingredient are generally formulated for daily use. Apply to clean skin before heavier creams or oils.

Glycylglycine oleamide appears to be well-tolerated in skincare formulations with no widely reported safety concerns. As with any cosmetic ingredient, perform a patch test if you have unusually reactive or sensitive skin.