Glycyrrhetinic Acid
Reviewed by Rosie · Last updated 18 Aug 2026
Also known as: Glycyrrhiza Glabra
Main ingredient found in licorice | Potent antioxidant properties
Addresses
EWG Safety Score
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What Is Glycyrrhetinic Acid?
Glycyrrhetinic acid is a bioactive compound that’s the main active ingredient found in the licorice plant (Glycyrrhiza glabra). While it’s most famously known for imparting licorice’s signature flavor, it’s also an important ingredient for maintaining healthy skin.
Scientific research demonstrates glycyrrhetinic acid has potent antioxidant properties to fight against the ravages of free-radical damage on skin. Recent studies show this acid is particularly effective in staving off the effects of UVB (ultraviolet B)-induced skin damage.
As if that weren’t impressive enough, research demonstrates glycyrrhetinic acid also exerts impressive anti-inflammatory effects on skin when applied topically. An indirect but often visible result of this trait is the minimization of dark patches and uneven tone.
The independent Cosmetic Ingredient Review panel has ruled glycyrrhetinic acid safe as used in cosmetics, where it is used in concentrations up to 2%. In fact, amounts even as high as 6% showed no indication of skin sensitization or irritation. Common use levels tend to fall between 0.5–1%, especially if this ingredient is used to support other ingredients known to fade hyperpigmentation and/or soothe skin.
Clinical Evidence & References
Published Research
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ScienceDirect.com, Website, Accessed August 2024 [URL]
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Biological Chemistry, April 2024, pages 407-415 [URL]
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Bioorganic & Medicinal Chemistry Letters, November 2022, ePublication [URL]
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Mediators of Inflammation, January 2021, pages 1-17 [URL]
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International Journal of Cosmetic Science, August 2019, pages 325-331 [URL]
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International Journal of Toxicology, March 2007, pages 79-112 [URL]
Frequently Asked Questions
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Take the skin quizOther forms of Glycyrrhetinic Acid
These appear on ingredients lists under different names but are the same substance. Glycyrrhetinic Acid is the common form.
Related Ingredients
Stearyl Glycyrrhetinate
Stearyl glycyrrhetinate is known for delivering significant
Glycine Soja Lipids
Plant-derived lipids that support skin hydration and natural moisture balance
Glycine Soja Phytoplacenta Extract
A soy-derived conditioning agent that helps soften skin and hair
Glycolipids
Lipid compounds that support the skin's natural barrier structure and hydration
Glycyrrhiza Glabra Callus Culture Extract
Plant cell culture extract with skin-conditioning properties
Glycyrrhiza Glabra Leaf Extract
A plant extract traditionally used to soothe and condition the skin
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