Skin Conditioning

Glycyrrhiza Glabra Callus Culture Extract

INCI: GLYCYRRHIZA GLABRA CALLUS CULTURE EXTRACT

Reviewed by Kate · Last updated 2 Jun 2026

Plant cell culture extract with skin-conditioning properties

Best For Skin Types

All, Sensitive, Dry

Addresses

Sensitivity, Dryness, Barrier repair

Usage Frequency

Daily

What Is Glycyrrhiza Glabra Callus Culture Extract?

Glycyrrhiza glabra callus culture extract is derived from liquorice plant cells grown in laboratory conditions through plant tissue culture. Rather than extracting compounds from the whole plant, this method cultivates undifferentiated plant cells that produce bioactive compounds associated with liquorice.

In skincare formulations, it functions primarily as a skin conditioning agent, helping to maintain skin texture and suppleness. The extract contains compounds traditionally linked to liquorice, though the specific bioactive profile of callus culture may differ from conventional plant extracts.

How It Works

Liquorice-derived compounds have been studied for their ability to interact with skin proteins and lipids that support barrier function and elasticity. The callus culture method produces these bioactive compounds in a controlled environment, which may offer consistency compared to traditional plant extraction.

The exact mechanisms in skincare remain partially understood, particularly for this specific extraction method. The ingredient likely works through humectant and emollient properties, supporting the skin's natural moisture balance and texture.

Clinical Evidence & References

Evidence specific to callus culture extracts of Glycyrrhiza glabra in skincare is limited. Most research on liquorice in skincare has focused on conventional plant extracts rather than cell culture-derived versions, making direct comparison difficult.

Liquorice compounds generally have demonstrated soothing and antioxidant properties in multiple studies, though the potency and bioavailability of callus culture extracts compared to traditional extracts remain unclear. Ingredient concentrations and formulation context significantly influence whether observable benefits occur.

How to Use

This ingredient is typically found in serums, moisturisers, and treatment products at concentrations unlikely to cause irritation. It can be incorporated into both morning and evening routines as part of a regular skincare regimen. Patch testing is advisable if you have particularly sensitive or reactive skin.

Safety & Precautions

Glycyrrhiza glabra callus culture extract is generally considered safe for topical use and well-tolerated across skin types. Liquorice-derived ingredients may occasionally trigger sensitivity in those with known allergies to the plant.

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