Human Plasma
INCI: HUMAN PLASMA
Reviewed by Daisy · Last updated 20 Jul 2026
A blood-derived concentrate rich in growth factors and proteins that support skin soothing and renewal
Best For Skin Types
All, Mature
Addresses
Usage Frequency
As directed by product instructions
What Is Human Plasma?
Human plasma is the liquid component of blood, containing proteins, growth factors, and other bioactive molecules. In skincare, it is typically derived from platelet-rich plasma (PRP)—an autologous concentrate prepared by processing a person's own blood to increase the concentration of platelets and their associated growth factors.
When applied topically or used in clinical procedures, human plasma functions as a skin conditioning agent. Its bioactive components interact with skin cells to support natural repair and renewal processes, particularly in response to injury or signs of aging.
How It Works
Human plasma contains growth factors such as VEGF, PDGF, and TGF-β, alongside plasma proteins and other signalling molecules. These components work together to stimulate cellular activity within the skin, encouraging angiogenesis (new blood vessel formation), collagen synthesis, and the production of hyaluronic acid—all key to skin structure and hydration.
When applied topically or used alongside clinical procedures such as microneedling, plasma components communicate with skin cells, triggering repair and renewal pathways. The exact mechanism varies depending on the preparation method and whether plasma is used alone or in combination with other treatments.
Clinical Evidence & References
Research suggests that platelet-rich plasma treatments can produce measurable improvements in multiple skin parameters, including pore size, texture, wrinkles, pigmentation, and collagen density. Most studies report improvements after one to three treatment sessions, with some evidence that combining plasma with other ingredients or procedures may enhance results.
However, the majority of evidence comes from clinical procedures rather than topical skincare products. The efficacy of human plasma in cosmetic formulations applied to intact skin is less extensively documented, and concentration levels in skincare products vary widely. Further research is needed to establish optimal concentrations and efficacy in non-procedural applications.
Published Research
How to Use
If using a topical product containing human plasma, apply as directed by the manufacturer, typically to clean skin. Plasma is often used as part of a layered routine and may be combined with other hydrating or nourishing products. If undergoing in-clinic plasma treatments, follow your practitioner's pre- and post-treatment guidance carefully, as aftercare is essential to optimal results.
Safety & Precautions
Frequently Asked Questions
From the Clinic
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Take the skin quizRelated Ingredients
Human Mononuclear Cell Conditioned Media Extract
A cell-derived extract designed to support skin conditioning and resilience
Human Neonatal Fibroblast Conditioned Media
Growth factor-rich cell culture extract that supports skin repair and resilience
Human Neonatal Fibroblast/Keratinocyte Conditioned Media
Cell-derived conditioning media that supports skin's natural renewal processes
Human Platelet Extract
A regenerative ingredient derived from human platelets to support skin recovery and conditioning
Human Umbilical Mesenchymal Stem Cell Exosomes
Cellular messaging particles that support skin repair and regeneration
Humic Acids
A naturally-derived conditioning agent with potential soothing properties
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