Human Platelet Extract

Human platelet extract (HPE) is derived from processed human platelets—specifically from leukocyte-reduced apheresed platelets sourced under controlled conditions. The extract contains exosomes, which are small extracellular vesicles naturally produced by cells that function as communication and regenerative mediators within skin tissue.In skincare formulations, HPE acts as a skin conditioning agent. The exosomes it contains carry bioactive compounds that may support skin repair processes and help improve overall skin health markers when used topically.

The exosomes in human platelet extract function as intercellular messengers. When applied topically, they may penetrate the skin or interact with surface cells to deliver bioactive compounds—including proteins, lipids, and signalling molecules—that naturally support skin repair and regeneration processes.This mechanism differs from occlusive moisturisers; HPE actively communicates with skin cells rather than simply coating the surface, though the full extent of dermal penetration and cellular uptake in topical application remains an area of ongoing research.

Human platelet extract is typically formulated as a serum for ease of application. Apply to clean skin, either morning or evening (or both, depending on formulation instructions), and allow to absorb before applying other products. It integrates well into standard skincare routines and can be used alongside other actives, though as with any new ingredient, introduce gradually to monitor tolerance.

Human platelet extract has demonstrated good tolerability in available research with no reported serious adverse effects. As an allogeneic (non-self) biological product, it is sourced under strict purity controls; however, individuals with sensitivities to biological ingredients or those with compromised skin barriers should patch-test first.