Magnesium Lithospermate B
INCI: MAGNESIUM LITHOSPERMATE B
Reviewed by Emma · Last updated 14 Aug 2026
Also known as: Magnesium Lithospermate B
A plant-derived compound studied for its role in supporting skin structure and resilience
Best For Skin Types
All, Mature, Dry
Addresses
Usage Frequency
Daily
What Is Magnesium Lithospermate B?
Magnesium lithospermate B is a naturally occurring compound isolated from Salvia miltiorrhiza (also known as danshen), a plant used in traditional Chinese medicine. It belongs to a class of molecules called depside salts and is valued in skincare formulations for its antioxidant and skin-conditioning properties.
In cosmetic products, this ingredient functions as an antioxidant to help protect skin from environmental stressors, whilst also offering humectant and skin-conditioning benefits that support the skin's appearance and feel.
Benefits for Your Skin
How It Works
Magnesium lithospermate B appears to work partly by activating PPARβ/δ, a nuclear receptor involved in regulating genes responsible for collagen production. When this pathway is activated, skin cells may increase their synthesis of collagen types I and III, which are key structural proteins that support skin firmness and elasticity.
The ingredient also exhibits antioxidant activity, helping to neutralise free radicals and reduce oxidative stress. Additionally, it may moderate inflammatory responses in the skin, which is relevant given that both intrinsic ageing and UV-induced damage involve inflammatory processes.
Clinical Evidence & References
Laboratory and animal studies suggest magnesium lithospermate B has potential anti-wrinkle effects. Research using aged skin models and UV-damaged human skin cells has shown it can help upregulate collagen expression and inhibit matrix metalloproteinases (MMPs) — enzymes that break down collagen. These findings suggest the ingredient may help counteract some aspects of skin ageing.
However, most available evidence comes from in vitro and animal studies rather than human clinical trials. Whilst these results are encouraging, the direct translation to visible effects in human skin remains to be comprehensively established. Safety data from medical use in injectable form indicates it is generally well-tolerated at therapeutic doses.
Published Research
How to Use
Magnesium lithospermate B is typically used as part of a broader skincare formulation rather than as a standalone ingredient. It works alongside other actives and base ingredients in serums, creams and treatments. As with any active ingredient, consistency of use is more important than occasional application, and it integrates well into both morning and evening routines.
Safety & Precautions
Frequently Asked Questions
From the Clinic
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