Madecassoside
INCI: Centella asiatica
Reviewed by Kate · Last updated 18 Aug 2026
Also known as: gotu kola
Potent Centella compound for targeted skin repair
At a glance
Addresses
EWG Safety Score
What Is Madecassoside?
Madecassoside is one of the primary active triterpene glycosides found in Centella Asiatica. Isolated and concentrated, it provides targeted anti-inflammatory and wound-healing benefits more potently than whole plant extracts.
This compound is particularly effective at calming skin inflammation and promoting the synthesis of Type I collagen. It represents a refined approach to harnessing Centella's benefits for sensitive and damaged skin.
Benefits for Your Skin
Clinical Evidence & References
- International Journal of Molecular Medicine, November 2024, pages 1–12
- Journal of Drug Delivery and Therapeutics, September 2024, pages 151-156
- Journal of Medicinal Food, December 2023, pages 919-926
- International Journal of Toxicology, June 2023, pages 5S-22S
- Journal of Cellular and Molecular Medicine, March 2023, pages 593-608
- Evidence-Based Complementary and Alternative Medicine, November 2021, pages 1–8
- Applied Sciences, September 2021, pages 1-29
- Journal of the Medical Sciences, July 2021, pages 274-289
How widely it's used
Regulatory information
Standardised cosmetic-ingredient identifiers used by regulators.
Show identifiers
- INCI Name
- MADECASSOSIDE
- EC Number
- 252-076-1
- Function
- Antioxidant, Skin Conditioning
Frequently Asked Questions
From the Clinic
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Maclura Cochinchinensis Leaf Prenyl Flavonoids
Subset of flavonoids extracted from the cockspur thorn
Magnesium Ascorbate/PCA
A stable form of vitamin C that works as an antioxidant to help protect skin from environmental stress
Magnesium Ascorbyl Phosphate
Stable, water-soluble Vitamin C for sensitive skin
Magnesium Lithospermate B
A plant-derived compound studied for its role in supporting skin structure and resilience
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