Madecassoside
INCI: Centella asiatica
Reviewed by Kate · Last updated 18 Aug 2026
Also known as: gotu kola
Potent Centella compound for targeted skin repair
Addresses
EWG Safety Score
What Is Madecassoside?
Madecassoside is one of the primary active triterpene glycosides found in Centella Asiatica. Isolated and concentrated, it provides targeted anti-inflammatory and wound-healing benefits more potently than whole plant extracts.
This compound is particularly effective at calming skin inflammation and promoting the synthesis of Type I collagen. It represents a refined approach to harnessing Centella's benefits for sensitive and damaged skin.
Benefits for Your Skin
Clinical Evidence & References
- International Journal of Molecular Medicine, November 2024, pages 1–12
- Journal of Drug Delivery and Therapeutics, September 2024, pages 151-156
- Journal of Medicinal Food, December 2023, pages 919-926
- International Journal of Toxicology, June 2023, pages 5S-22S
- Journal of Cellular and Molecular Medicine, March 2023, pages 593-608
- Evidence-Based Complementary and Alternative Medicine, November 2021, pages 1–8
- Applied Sciences, September 2021, pages 1-29
- Journal of the Medical Sciences, July 2021, pages 274-289
Frequently Asked Questions
From the Clinic
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Lycium Chinense Fruit Extract
A plant extract with antioxidant properties, traditionally used in Eastern medicine
Lycopene
Tomato-derived carotenoid for potent protection
Maclura Cochinchinensis Leaf Prenyl Flavonoids
Subset of flavonoids extracted from the cockspur thorn
Magnesium Ascorbate/PCA
A stable form of vitamin C that works as an antioxidant to help protect skin from environmental stress
Magnesium Ascorbyl Phosphate
Stable, water-soluble Vitamin C for sensitive skin
Magnesium Lithospermate B
A plant-derived compound studied for its role in supporting skin structure and resilience
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