Matrine
INCI: MATRINE
Reviewed by Daisy · Last updated 14 Aug 2026
A plant-derived antioxidant traditionally used to address inflammatory skin conditions
Best For Skin Types
Sensitive, All
Addresses
Usage Frequency
Daily
What Is Matrine?
Matrine is an alkaloid compound extracted from Sophora flavescens, a plant with a long history in traditional medicine. In skincare formulations, it functions as an antioxidant and skin conditioning agent, working to protect skin from oxidative stress whilst supporting the skin's natural resilience.
The ingredient is incorporated into products in relatively modest concentrations and appears in a small proportion of skincare ranges, primarily in formulations targeting reactive or inflamed skin states.
Benefits for Your Skin
How It Works
Matrine is believed to work through multiple pathways. It acts as an antioxidant by neutralising free radicals, which can otherwise trigger inflammatory cascades in the skin. Additionally, preliminary research suggests it may influence immune-related signalling pathways that contribute to inflammatory skin conditions, potentially helping to restore balance in overactive skin responses.
Clinical Evidence & References
Research into matrine has primarily focused on atopic dermatitis and inflammatory skin conditions. Laboratory and animal studies suggest the ingredient may help reduce inflammation markers and improve skin barrier function in these contexts. However, human clinical trial data remains limited, and most evidence comes from controlled laboratory settings rather than large-scale human studies.
Whilst the research direction is promising, more extensive human trials would help establish its efficacy and optimal use in cosmetic formulations. Current evidence supports its inclusion as part of a broader skincare approach to reactive skin, rather than as a standalone solution.
Published Research
How to Use
Matrine is typically found in serums, creams, and targeted treatment products. It can be used daily as part of your routine, often as part of a multi-ingredient formulation. If your skin is particularly reactive, introduce it gradually and observe how your skin responds over a few weeks before committing to regular use.
Safety & Precautions
Frequently Asked Questions
From the Clinic
Not sure what your skin actually needs?
Two minutes, a few questions, and we’ll point you at what matters — no guesswork.
Take the skin quizRelated Ingredients
Malus Domestica Fruit Extract
Apple fruit extract rich in polyphenols, used primarily for its antioxidant properties
Mangifera Indica Leaf Extract
From the leaf of the mango plant
Matricaria Maritima Extract
A coastal plant extract with antioxidant and skin-conditioning properties
Meadowsweet Extract
Natural source of salicylic acid precursors
Melaleuca Alternifolia Leaf Oil
An essential oil with purifying properties, traditionally used for skin concerns
Melatonin
A natural antioxidant that supports skin resilience and microbiota balance
Learn More About Skincare Ingredients
Explore our comprehensive ingredient glossary to understand what's in your products.
Browse All IngredientsShop Our Products
Find professional skincare solutions at Skintique.