MSM
INCI: Methylsulfonylmethane
Reviewed by Emma · Last updated 18 Aug 2026
Also known as: Dimethyl Sulfone
Organic sulfur compound for skin structure
Addresses
EWG Safety Score
What Is MSM?
MSM (Methylsulfonylmethane) is a naturally occurring organic sulfur compound essential for the production of collagen, keratin, and elastin. It provides the sulfur needed for these critical structural proteins.
Beyond structural support, MSM offers anti-inflammatory benefits and helps improve skin permeability for better absorption of other ingredients. It is a fundamental building block for healthy skin.
Clinical Evidence & References
- N Muizzuddin, R Benjamin. Beauty from within: Oral administration of a sulfur-containing supplement methylsulfonylmethane improves signs of skin ageing. International Journal for Vitamin and Nutrition Research, 2020
- M Butawan, RL Benjamin, RJ Bloomer. Methylsulfonylmethane: applications and safety of a novel dietary supplement. Nutrients, 2017
- E Berardesca, N Cameli, C Cavallotti. Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: clinical and instrumental evaluation. Journal of cosmetic dermatology, 2008
- SG CHU. Effects of Methylsulfonylmethane on UVB-induced Skin Damage in Mice. The Journal of Dermatology, 2022
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