Nicotinoyl Tripeptide-1

Nicotinoyl Tripeptide-1 is a synthetic peptide—a short chain of amino acids—combined with niacin (vitamin B3). It functions as both an antioxidant and a chelating agent, meaning it can neutralise free radicals and bind to metal ions that may otherwise trigger oxidative stress in the skin.The ingredient is engineered to support the skin's natural defence mechanisms. By providing antioxidant protection, it aims to help preserve skin integrity and reduce visible signs of environmental damage over time.

Nicotinoyl Tripeptide-1 works through two primary mechanisms. As an antioxidant, it donates electrons to neutralise free radicals—unstable molecules that can damage skin cells and accelerate visible ageing. As a chelating agent, it binds to metal ions (such as iron and copper) that would otherwise catalyse free radical formation, reducing their harmful activity.The niacin component may also support skin barrier function and reduce inflammation, complementing the peptide's protective role. Together, these functions aim to help preserve skin quality and resilience against environmental insult.

Use Nicotinoyl Tripeptide-1 as part of a layered routine: apply it to clean skin before heavier creams or oils to allow optimal absorption. It works well in serums, essences, and lightweight moisturisers. Pair it with broad-spectrum sunscreen during the day, since environmental stressors it helps protect against are often UV-related. There is no specific upper limit on daily use, though once or twice daily is typical.

Nicotinoyl Tripeptide-1 is generally well-tolerated and rarely cited as an irritant. However, if you have niacin sensitivity or severe reactive skin, patch test first. If you're pregnant or breastfeeding, please check with us first — hello@skintique.co.uk.