Nonoxynol-9
INCI: NONOXYNOL-9
Reviewed by Emma · Last updated 14 Aug 2026
A surfactant that stabilises formulations and helps ingredients blend evenly
Best For Skin Types
All
Effective Concentrations
0.0008–5%
Usage Frequency
As directed in product instructions
What Is Nonoxynol-9?
Nonoxynol-9 is a nonionic surfactant—a type of cleaning agent derived from nonylphenol and ethylene oxide. It belongs to the broader family of alkylphenol ethoxylates, which are widely used across cosmetic and personal care formulations.
In skincare products, nonoxynol-9 functions primarily as an emulsifying and solubilising agent. This means it helps oil and water-based ingredients mix together smoothly and remain stable in a formula, preventing separation over time. It can also assist in cleansing formulations by reducing the surface tension of water.
How It Works
Nonoxynol-9 is an amphiphilic molecule, meaning it has both water-loving and oil-loving regions. This dual nature allows it to position itself at the boundary between oil and water, holding them in suspension rather than allowing them to separate. In this role, it acts as a molecular bridge.
In cleansing products, it works by lowering water's surface tension, which helps lift oils and impurities from the skin surface more effectively than water alone.
Clinical Evidence & References
Published safety assessments have evaluated nonoxynol-9 alongside related alkylphenol ethoxylates and found them to be safe for use in cosmetics at typical concentrations (generally below 5%). The ingredient has a long history of use in various formulations without widespread reports of adverse effects at these levels.
Most evidence concerning nonoxynol-9 relates to its historical use in contraceptive products rather than skincare specifically, so direct clinical data on skin outcomes in cosmetic formulations is limited. Its primary role remains functional rather than therapeutic.
Published Research
How to Use
Nonoxynol-9 is a formulation ingredient rather than an active treatment, so its benefits are indirect—it simply helps your other skincare ingredients work as intended. Use products containing it as directed on the label, and store them away from direct sunlight to preserve formulation stability.
Safety & Precautions
Frequently Asked Questions
From the Clinic
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