Peptides

Oligopeptide-22

INCI: OLIGOPEPTIDE-22

Reviewed by Kate · Last updated 14 Aug 2026

A peptide that supports skin conditioning and structural resilience

Best For Skin Types

All, Dry, Mature, Combination

Addresses

Fine lines, Elasticity, Hydration

Usage Frequency

Daily

What Is Oligopeptide-22?

Oligopeptide-22 is a peptide—a short chain of amino acids—designed to function as a skin conditioning agent. Peptides are fragments of proteins that are small enough to penetrate the skin's outer layers, making them useful ingredients in cosmetic formulations.

This ingredient works primarily to improve skin texture and condition by interacting with the skin's natural structures. It is typically used in serums, moisturisers, and treatment products at concentrations that vary depending on the formulation.

How It Works

Oligopeptide-22 works by conditioning the skin—essentially improving its appearance and tactile quality. As a peptide, it is smaller than full-size proteins, which allows it to interact with the outer layers of the epidermis more readily than larger molecules.

The ingredient supports skin's natural functions by engaging with the skin's structural components. Because skin ages partly through a gradual loss of collagen and a thinning of the epidermis and dermis, ingredients that support skin conditioning may help maintain a more resilient and youthful appearance.

Clinical Evidence & References

Research into skin ageing demonstrates that the skin undergoes significant structural changes with time, including loss of dermal collagen and thinning of both epidermal and dermal layers. Peptides as a category have been studied for their potential to support skin structure and appearance, though the specific clinical evidence for Oligopeptide-22 in peer-reviewed literature is limited.

Most of what we know about this ingredient comes from its use in cosmetic formulations rather than extensive independent clinical trials. It is positioned as a conditioning agent that supports skin quality, but consumers should be aware that large-scale clinical studies specifically validating its efficacy are not readily available in published research.

How to Use

Oligopeptide-22 is typically found in serums and moisturisers where it can be applied to clean skin once or twice daily. For best results, apply to damp skin to support hydration, and allow the product to absorb before applying sunscreen or other products. It can be layered with other actives, though patch testing is sensible if you have sensitive skin.

Safety & Precautions

Peptides are generally well-tolerated by most skin types. There are no widely reported safety concerns with Oligopeptide-22, though individuals with known sensitivities to peptide-based products should patch test first.

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