Best For Skin Types
All
Addresses
Usage Frequency
Daily
What Is Oligopeptide-28?
Oligopeptide-28 is a short chain peptide—a fragment of amino acids—designed to function as an antioxidant and protective agent in skincare formulations. Peptides are valued in cosmetics because they are relatively small molecules that can be incorporated into products without the stability concerns of larger proteins.
In formulation, this ingredient serves multiple roles: it neutralises free radicals that damage skin cells, binds to other components to improve product stability, and helps protect the skin barrier from external stressors. It is typically used in concentrations that support these protective functions without unnecessary accumulation.
Benefits for Your Skin
How It Works
Oligopeptide-28 functions primarily as an antioxidant by donating electrons to unstable free radical molecules, rendering them harmless. Free radicals are generated by sun exposure, pollution, and natural metabolic processes, and accumulate over time to damage skin cells and accelerate visible signs of ageing.
Beyond antioxidation, this peptide also acts as a chelating agent—it binds to trace metals that can trigger oxidative damage in the skin—and contributes to skin barrier function by reinforcing the skin's natural protective mechanisms. These combined actions position it as a preventative rather than corrective ingredient.
Clinical Evidence & References
Research confirms that skin ageing involves progressive loss of structural proteins (particularly collagen) and cumulative oxidative damage to both the epidermis and dermis. Antioxidant ingredients are well-established as part of a protective skincare strategy to slow these processes, and peptides are recognised for their biocompatibility and stability in formulations.
However, specific clinical data on oligopeptide-28 alone is limited in published literature. Most evidence for peptide-based antioxidants comes from broader category research rather than ingredient-specific studies. Its inclusion in skincare products is supported by its functional classification, but individual efficacy claims warrant cautious interpretation.
How to Use
Oligopeptide-28 is typically found in serums, moisturisers, and protective treatments. It works well as part of a layered routine alongside sunscreen and other antioxidants; combining complementary antioxidants (such as vitamin C or niacinamide) may offer broader free radical protection. Apply to clean skin before moisturiser, or use as directed on the product label.
Safety & Precautions
Frequently Asked Questions
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