Oligopeptide-29

Oligopeptide-29 is a short chain peptide—a fragment of amino acids—designed to support skin's natural defences. As a synthetic ingredient, it functions as an antioxidant and skin protectant, helping to shield the skin from environmental stressors and maintain barrier integrity.Peptides are valued in skincare because they can interact with skin cells in ways that support structural and functional health. Oligopeptide-29 is found in a relatively small percentage of skincare formulations, suggesting it remains a specialist rather than mainstream ingredient.

Oligopeptide-29 works through multiple mechanisms. As an antioxidant, it helps counteract free radical damage—unstable molecules that accumulate from sun exposure, pollution, and natural metabolism, and which contribute to visible signs of ageing.Its chelating properties allow it to bind metals that might otherwise trigger oxidative reactions in the skin. Through these combined actions, the ingredient is intended to support skin resilience and reduce the pace of damage that contributes to visible ageing.

Oligopeptide-29 is typically found in serums, moisturisers, and treatment products at low concentrations. As with most peptide ingredients, it works best when applied to clean skin and layered with complementary actives such as vitamin C or niacinamide. It is not known to cause sensitivity in most skin types, so can generally be incorporated into both morning and evening routines.

Oligopeptide-29 is generally well-tolerated and is not associated with common sensitising effects. As with all skincare ingredients, patch testing before full application is sensible if you have very sensitive skin.