Addresses
EWG Safety Score
What Is Oligopeptide-3?
Oligopeptide-3 is a synthetic (lab-engineered) peptide made up of the amino acids alanine, lysine, phenylalanine, and tridecapeptide with leucine.
Manufacturers of oligopeptide-3, also known by the trade name Creapep ®, claim it binds with skin cell receptors to trigger increases of elastin, hyaluronic acid, and factors that increase skin resilience to fight visible signs of aging.
While there isn’t yet a breadth of independent, peer-reviewed research backing some of these claims, peptides are hydrating and skin conditioning ingredients that do help improve the look and feel of skin.
The recommended use level of oligopeptide-3 in skin care products is 0.01–0.1%, which speaks to the potency of this peptide and its affinity for skin.
Clinical Evidence & References
Published Research
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ULProspector, Website, Accessed August 2025 [https://www.ulprospector.com/en/eu/PersonalCare/Detail/126262/7083850/Creapep-Oligopeptide-3]
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SpecialChem, Website, Accessed August 2025 [https://www.specialchem.com/cosmetics/product/tidetronbio-creapep-oligopeptide-3]
Frequently Asked Questions
From the Clinic
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Oligopeptide-25
A peptide fragment that supports skin conditioning and structural integrity
Oligopeptide-28
A peptide-derived antioxidant that helps protect skin from environmental stress
Oligopeptide-29
A peptide with antioxidant and skin-protecting properties
Oligopeptide-32
A peptide that may help regulate sebum production and condition the skin barrier
Oligopeptide-34
A peptide that supports skin conditioning and structural integrity
Oligopeptide-35
A peptide fragment that supports skin conditioning and structural integrity
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