Peptides

Oligopeptide-78

INCI: OLIGOPEPTIDE-78

Reviewed by Kate · Last updated 2 Jun 2026

A peptide fragment that supports skin conditioning and structural integrity

Best For Skin Types

All, Mature, Dry

Addresses

Fine lines, Hydration, Elasticity

Usage Frequency

Daily

What Is Oligopeptide-78?

Oligopeptide-78 is a short-chain peptide — a small protein fragment composed of amino acids linked together. Peptides are recognised by the skin as building blocks similar to those found naturally in skin tissue, particularly in collagen and elastin, the structural proteins that give skin its firmness and resilience.

In skincare formulations, oligopeptide-78 functions primarily as a skin conditioning agent. Its role is to help support the skin's natural structural proteins and maintain skin hydration and elasticity at a cellular level.

How It Works

As we age, the dermis gradually loses collagen and the epidermis thins, leading to visible changes in texture, firmness, and elasticity. Peptides like oligopeptide-78 are small enough to penetrate the outer layers of skin where they can interact with skin cells and provide amino acid building blocks.

These peptide fragments are thought to signal to skin cells and support the maintenance of the skin's natural protein structures. By providing these molecular building blocks, oligopeptide-78 helps condition the skin and supports its natural barrier function and hydration capacity.

Clinical Evidence & References

Research demonstrates that aged skin is characterised by a progressive loss of dermal collagen and epidermal thinning, which impairs skin structure and function. Peptides are included in skincare formulations based on the principle that they can help address these structural changes by supporting the skin's natural protein synthesis.

However, specific clinical evidence for oligopeptide-78 in particular is limited in the available literature. General peptide research suggests they can improve skin hydration and support skin conditioning, though the degree of effect varies depending on formulation, concentration, and individual skin characteristics. More targeted research on this specific peptide would help clarify its efficacy.

How to Use

Oligopeptide-78 is typically found in serums, moisturisers, and targeted treatments. It works well alongside other skin conditioning and hydrating ingredients. Apply to clean skin and layer with other products as part of your regular routine — peptides are generally well-suited to daily use and integrate easily into most skincare regimens.

Safety & Precautions

Oligopeptide-78 is generally well-tolerated by most skin types. As a peptide derived from amino acids, it is unlikely to cause irritation, though those with sensitive skin should introduce it gradually.

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