Palmitoyl Tripeptide-28

Palmitoyl tripeptide-28 is a synthetic peptide—a short chain of amino acids—modified with a fatty acid (palmitic acid) attachment. This modification, known as palmitoylation, is designed to improve the ingredient's ability to penetrate the skin and interact with cellular structures.In formulations, it functions primarily as a skin conditioning agent, with formulators including it to support the skin's structural proteins and overall condition. It appears in a range of skincare products, though it remains less commonly used than some other peptide variants.

Peptides work by signalling to skin cells, encouraging them to maintain or produce structural proteins such as collagen and elastin. The palmitoyl modification on this tripeptide is intended to help the molecule cross the skin barrier more effectively, allowing it to reach deeper layers where these proteins are synthesised.Once in the skin, the peptide may interact with fibroblasts—the cells responsible for producing extracellular matrix components—to support their normal maintenance and repair processes.

Palmitoyl tripeptide-28 is typically used in serums, eye creams and moisturisers. Apply to clean skin before heavier creams, or layer with other actives according to your routine. There is no established maximum daily frequency; use as directed on the product label. It pairs well with hydrating and barrier-supporting ingredients, though combining multiple peptide products is unnecessary.

Palmitoyl tripeptide-28 is generally well-tolerated, though as with any peptide ingredient, patch testing is prudent if you have particularly reactive skin. Some users flag potential concerns about fungal acne compatibility; if you are prone to malassezia-related breakouts, check the full product formulation or consult a dermatologist.