Peptides

Pentapeptide-31

INCI: PENTAPEPTIDE-31

Reviewed by Rosie · Last updated 2 Jun 2026

A peptide that supports skin conditioning and structural integrity

Best For Skin Types

All, Dry, Mature

Addresses

Fine lines, Dryness, Hydration

Usage Frequency

Daily

What Is Pentapeptide-31?

Pentapeptide-31 is a short chain peptide — a fragment of amino acids — used in skincare formulations as a skin conditioning agent. Peptides are naturally occurring in the skin and play a role in maintaining its structure and resilience.

In cosmetic products, pentapeptide-31 functions as a skin conditioning ingredient, meaning it helps to improve the texture, appearance and feel of the skin when applied topically.

How It Works

Peptides work by signalling to skin cells and supporting the skin's natural structural proteins. Pentapeptide-31 conditions the skin surface, helping to improve hydration and the overall feel of the skin.

Rather than acting as a direct treatment for specific concerns, this ingredient functions as a supportive component within skincare formulations, working to maintain skin condition and resilience.

Clinical Evidence & References

Research on peptides in general shows that the skin undergoes structural changes with age, including loss of collagen and thinning of both the epidermis and dermis. Peptides are studied for their potential to support skin structure, though specific clinical evidence on pentapeptide-31 itself is limited in published literature.

The ingredient is primarily used for its skin conditioning properties rather than as a targeted treatment for a specific skin concern. More independent research would help clarify its efficacy compared to other peptide options available.

How to Use

Pentapeptide-31 is typically found in serums, moisturisers and other leave-on products. It can be incorporated into most skincare routines without special considerations. Layer it with other active ingredients as you would normally, following the formulation instructions on your product.

Safety & Precautions

Peptides are generally well-tolerated by most skin types. As with any skincare ingredient, discontinue use if irritation occurs and perform a patch test if you have particularly sensitive skin.

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