Prebiotic/Probiotic/Postbiotic

Pichia Pastoris … Filtrate

INCI: PICHIA PASTORIS/DIETHYLHEXYL SYRINGYLIDENEMALONATE/TOCOPHEROL FERMENT EXTRACT FILTRATE

Reviewed by Kate · Last updated 2 Jun 2026

A fermented yeast extract that conditions and supports skin's natural protective functions

Best For Skin Types

All, Dry, Sensitive, Mature

Addresses

Dryness, Hydration, Barrier repair

Usage Frequency

Daily

What Is Pichia Pastoris … Filtrate?

This ingredient is a fermentation filtrate derived from Pichia Pastoris, a species of yeast commonly used in biotechnology. The fermentation process produces bioactive compounds that are then combined with diethylhexyl syringylidenemalonate and tocopherol (vitamin E) to create a skin-conditioning complex.

The resulting blend functions primarily as a humectant and skin conditioner, helping to support the skin's moisture retention and overall barrier health. Because it comes from fermentation, it may contain amino acids, peptides, and other small molecules that can penetrate the skin's outer layers.

How It Works

Fermented ingredients work by breaking down larger molecules into smaller, more bioavailable forms through enzymatic action. This allows the compounds to interact more effectively with the skin's outer layers. The yeast filtrate likely delivers amino acids and small peptides that can be incorporated into the skin's natural moisturising factor.

The addition of tocopherol (vitamin E) provides antioxidant support, helping to neutralise free radicals and reduce oxidative stress on the skin. Together, these components work to condition the skin and maintain hydration levels.

Clinical Evidence & References

Published research specifically on this multi-component ingredient is limited. However, fermented yeast extracts have shown promise in skincare research for their ability to support skin hydration and barrier function, largely due to their amino acid and peptide content.

Vitamin E is well-documented as an effective antioxidant and skin conditioner. Evidence supports its role in maintaining skin health and protecting against environmental damage. The evidence base for this specific combination is modest, so results may vary between individuals and formulations.

How to Use

This ingredient is typically found in moisturisers, serums, and conditioning treatments. Use as directed by the product formulation — usually once or twice daily. It works well in layered routines and pairs effectively with other hydrating and barrier-supporting ingredients such as hyaluronic acid or ceramides.

Safety & Precautions

Generally well-tolerated across skin types. Fermented ingredients are considered safe for cosmetic use, though those with yeast sensitivities should patch-test first.

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