Humectant

Placental Protein

INCI: PLACENTAL PROTEIN

Reviewed by Kate · Last updated 14 Aug 2026

A protein-rich extract that helps skin retain moisture and maintain hydration

Best For Skin Types

All, Dry, Mature

Addresses

Dryness, Hydration, Barrier repair

Usage Frequency

Daily

What Is Placental Protein?

Placental Protein is a protein extract derived from animal placental tissue. In skincare formulations, it functions primarily as a humectant — an ingredient that draws water into the skin and helps it retain moisture.

The placenta is rich in proteins and bioactive compounds, which is why it has been studied for potential applications in skincare and regenerative medicine. When incorporated into cosmetic products, placental protein works to support the skin's natural moisture-binding capacity.

How It Works

Placental Protein functions as a humectant, meaning it has hygroscopic properties that allow it to bind water molecules. When applied topically, it draws moisture into the outer layers of the skin, which can help improve hydration levels and skin feel.

The protein component also provides amino acids — building blocks that support skin health. These may contribute to maintaining skin structure and supporting natural repair processes, though the extent to which topically applied proteins penetrate and influence skin function remains an active area of research.

Clinical Evidence & References

The safety profile of placental proteins in cosmetics has been formally assessed and they are considered safe for use in skincare products. Research into placental-derived materials has focused on their potential in regenerative medicine and cell development, demonstrating the presence of bioactive compounds.

However, evidence specifically demonstrating efficacy of topically applied placental protein in skincare formulations is limited. Most claims rest on its established humectant properties and protein content rather than robust clinical studies in humans. More research would help clarify whether benefits extend beyond standard hydrating ingredients.

How to Use

Placental Protein is typically incorporated into serums, moisturisers, and masks at concentrations that support hydration. It works well in formulations combined with other humectants and occlusives, which lock in the moisture it helps draw to the skin. Apply to damp skin for optimal hydration benefit, or layer under a moisturiser to seal in hydration.

Safety & Precautions

Placental Protein is well-tolerated in cosmetic formulations and has been assessed as safe for use. Those with sensitivities to animal-derived ingredients should check product labelling or source, as this ingredient originates from animal tissue.

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