Exfoliants

Polyhydroxybutyrate

INCI: POLYHYDROXYBUTYRATE

Reviewed by Emma · Last updated 14 Aug 2026

A biopolymer exfoliant derived from bacterial fermentation with potential skin conditioning properties

Best For Skin Types

All

Addresses

Dullness, Uneven texture

Usage Frequency

1-3 times per week

What Is Polyhydroxybutyrate?

Polyhydroxybutyrate (PHB) is a biopolymer produced through bacterial fermentation, making it a naturally derived alternative to synthetic exfoliants. In skincare formulations, it functions as both an abrasive and skin conditioning agent, offering a gentler mechanical exfoliation option compared to some traditional scrub particles.

The material is biocompatible and biodegradable, which has prompted research into its use in wound healing and tissue engineering applications. When incorporated into topical products at low concentrations, it provides gentle physical exfoliation whilst maintaining skin integrity.

Benefits for Your Skin

How It Works

Polyhydroxybutyrate works as a physical exfoliant through its particulate structure, which gently buffs away dead skin cells and surface impurities when massaged onto damp skin. Unlike chemical exfoliants that dissolve the bonds between skin cells, PHB provides mechanical action that is gentler and more controllable.

Beyond exfoliation, PHB has conditioning properties that help protect the skin barrier during this process. Research into its wound-healing applications suggests it may support skin hydration and comfort, which translates to a more balanced exfoliation experience that doesn't compromise skin health.

Clinical Evidence & References

Most research on polyhydroxybutyrate focuses on its potential in wound dressing and tissue engineering rather than cosmetic exfoliation. Studies show that PHB-based scaffolds can support skin healing and reduce scarring when combined with stem cells, demonstrating good biocompatibility and mechanical stability in healing wounds.

Evidence specifically for its use as a topical exfoliant in routine skincare is limited. Whilst the ingredient's safety profile and skin-conditioning properties are promising, more targeted cosmetic research would help establish optimal concentrations and efficacy for general exfoliation purposes.

How to Use

Use polyhydroxybutyrate-containing products 1-3 times weekly depending on skin sensitivity and tolerance. Apply to damp skin, gently massage in circular motions for 1-2 minutes, then rinse thoroughly with lukewarm water. Follow with your regular hydrating toner, essence, or moisturiser to lock in hydration. Start with lower frequency if your skin is sensitive or compromised, and discontinue if irritation develops.

Safety & Precautions

Polyhydroxybutyrate is generally well-tolerated and biocompatible. As with all physical exfoliants, avoid use on active acne lesions, open wounds, or severely inflamed skin, and do not over-exfoliate.

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