Humectant

Rhamnose

INCI: RHAMNOSE

Reviewed by Daisy · Last updated 14 Aug 2026

A simple sugar with emerging evidence for supporting skin's structural integrity

Best For Skin Types

All, Dry, Mature

Addresses

Fine lines, Dryness, Hydration, Loss of elasticity

Usage Frequency

Daily

What Is Rhamnose?

Rhamnose is a naturally occurring six-carbon sugar (deoxyhexose) found in plant cell walls and polysaccharides. In skincare formulations, it functions as a humectant—drawing moisture into the skin—and can also serve a masking function to improve product texture and feel.

The ingredient appears in roughly 0.2% of skincare products, typically at modest concentrations. It is derived from natural sources and is used primarily for its potential skin-conditioning properties rather than as a preservative or active in the traditional sense.

How It Works

Rhamnose appears to work at the cellular level, particularly within dermal fibroblasts—the cells that produce and maintain collagen and elastin. The available evidence suggests it may help these cells function optimally and resist some of the biochemical changes associated with aging, such as the accumulation of glycated proteins.

As a humectant, rhamnose also works on the surface and upper layers of skin by drawing water molecules into the stratum corneum, helping to maintain hydration levels and support the skin's barrier function.

Clinical Evidence & References

In vitro studies using reconstructed skin models and aged fibroblasts show that rhamnose may have beneficial effects on both the epidermis and dermis, with some evidence of increased collagen IV and procollagen I production. Research has also explored its potential to counter mechanisms of skin aging, including glycation and oxidative damage.

However, human clinical evidence remains limited. Most studies are laboratory-based or conducted on reconstructed tissue rather than in vivo human trials, so the degree to which these benefits translate to visible skin improvement in real-world use is not yet fully established. Further research in human subjects would help clarify its practical efficacy.

How to Use

Rhamnose is typically found as a supporting ingredient in serums, moisturisers, and hydrating products rather than as a standalone active. Use products containing it as directed, morning and evening as part of your regular skincare routine. It pairs well with other humectants and antioxidants, and is generally gentle enough for layering with other ingredients.

Safety & Precautions

Rhamnose is a naturally derived carbohydrate with a favourable safety profile and is generally well-tolerated across skin types. No significant adverse effects have been reported in cosmetic use at typical concentrations.

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