Emollient

Sh-Polypeptide-58

INCI: SH-POLYPEPTIDE-58

Reviewed by Daisy · Last updated 18 Aug 2026

What Is Sh-Polypeptide-58?

sh-Polypeptide-58 is a single chain synthetic human peptide, produced by fermentation in E.Coli. The starting gene is a synthesized copy of the human gene which codes for Tissue Inhibitor for Metalloproteinase 1 used as such or adapted to the production host. It contains a maximum of 207 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids.

Its declared cosmetic functions are emollient, skin conditioning and skin protecting.

Source: European Commission CosIng inventory.

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