Peptides

Sh-Polypeptide-59

INCI: SH-POLYPEPTIDE-59

Reviewed by Rosie · Last updated 2 Jun 2026

A peptide that supports skin conditioning and surface hydration

Best For Skin Types

All, Dry, Mature

Addresses

Hydration, Dryness

Usage Frequency

Daily

What Is Sh-Polypeptide-59?

Sh-Polypeptide-59 is a synthetic peptide—a short chain of amino acids—designed to function as a skin conditioning agent. Peptides in skincare are valued for their small molecular weight, which allows them to interact with the skin's surface and potentially penetrate the outer layers.

This ingredient works primarily to improve skin's moisture retention and texture, contributing to a smoother, more supple appearance. It is typically incorporated into serums, moisturisers, and treatment formulas at modest concentrations.

How It Works

As a peptide, Sh-Polypeptide-59 is thought to condition the skin by binding to the outer layers and supporting the skin's natural moisture barrier. This helps reduce transepidermal water loss and can make skin feel softer and appear more uniform.

The exact mechanism is not extensively documented in published literature, but peptides generally function through their hygroscopic (water-attracting) properties and their ability to form a protective film on the skin surface.

Clinical Evidence & References

Published clinical data specifically on Sh-Polypeptide-59 is limited. Most information about this ingredient comes from supplier specifications and cosmetic formulation databases rather than independent peer-reviewed studies.

General peptide research suggests that these ingredients can improve skin hydration and appearance when applied topically, though results tend to be modest and short-term. Further independent research would help clarify the efficacy profile of this particular peptide.

How to Use

Sh-Polypeptide-59 is best used as part of a hydrating serum or moisturiser applied to clean skin. It works well in layered routines and can be used daily as part of your regular skincare regimen. For best results, apply to slightly damp skin to support moisture absorption.

Safety & Precautions

Generally well-tolerated with low irritancy potential. As with any ingredient, discontinue use if signs of irritation develop. Suitable for most skin types, including sensitive skin.

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