Peptides

Sh-Polypeptide-5

INCI: SH-POLYPEPTIDE-5

Reviewed by Daisy · Last updated 2 Jun 2026

A peptide fragment that supports skin conditioning and structural integrity

Best For Skin Types

All, Dry, Sensitive, Mature

Addresses

Dryness, Hydration, Barrier repair

Usage Frequency

Daily

What Is Sh-Polypeptide-5?

Sh-Polypeptide-5 is a synthetic peptide—a short chain of amino acids—designed to function as a skin conditioning agent. Peptides in skincare work by mimicking or supporting the body's natural amino acid structures, which form the basis of proteins like collagen and elastin that maintain skin firmness and texture.

This particular peptide is used in formulations to help maintain skin's moisture barrier and overall condition. As a conditioning ingredient, it aims to keep the skin's surface smooth and comfortable rather than triggering dramatic structural changes.

How It Works

Peptides work by signalling to skin cells or by integrating into the skin's surface layers to reinforce moisture retention and structural integrity. Sh-Polypeptide-5 functions primarily as a humectant and conditioning agent, drawing water into the outer layers of skin and helping to bind moisture there.

While peptides are sometimes marketed as collagen-stimulating, the evidence for systemic penetration and deep structural remodelling is limited. This ingredient is best understood as a surface-level conditioning support rather than a transformative anti-ageing agent.

Clinical Evidence & References

Published clinical data specifically on Sh-Polypeptide-5 is sparse. Like many peptide ingredients, it is supported primarily by supplier data and in vitro studies rather than independent human trials. These suggest benefits for skin hydration and smoothness when used in formulation.

Peptides as a category show promise for barrier support, but individual peptides vary in their effects. Claims about deep collagen remodelling should be viewed with caution; most evidence points to surface conditioning benefits.

How to Use

Sh-Polypeptide-5 is gentle and suitable for regular use, typically found in serums, moisturisers and hydrating masks. Apply to clean skin and layer with other hydrating or active ingredients as desired. No special timing or restrictions apply, making it a straightforward addition to most routines.

Safety & Precautions

Generally well-tolerated across skin types. Peptides are unlikely to cause irritation, though patch testing is always sensible if you have extremely sensitive or reactive skin.

Frequently Asked Questions

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