Peptides

Sh-Polypeptide-62

INCI: SH-POLYPEPTIDE-62

Reviewed by Emma · Last updated 2 Jun 2026

A peptide-derived ingredient that supports skin structure and antioxidant defence

Best For Skin Types

All, Mature, Dry, Sensitive

Addresses

Fine lines, Dryness, Barrier repair

Usage Frequency

Daily

What Is Sh-Polypeptide-62?

Sh-Polypeptide-62 is a peptide—a short chain of amino acids—derived from plant or animal sources depending on formulation. Peptides are fragments smaller than full proteins, which allows them to penetrate the skin more effectively and communicate with skin cells to support natural repair and maintenance processes.

In skincare formulations, this ingredient functions as an antioxidant and conditioning agent. It helps protect skin from oxidative stress and supports the skin's natural barrier function, contributing to a smoother, more resilient complexion.

Benefits for Your Skin

How It Works

As the skin ages, it experiences a gradual loss of structural proteins and a decline in its natural defence systems. Peptides like Sh-Polypeptide-62 work by signalling to skin cells to maintain their function and by providing antioxidant activity—meaning they help neutralise reactive molecules (free radicals) that accumulate from sun exposure and environmental stress.

By supporting the skin's own repair mechanisms and reducing oxidative damage, this ingredient helps maintain skin firmness and a more youthful appearance over time. The conditioning properties also help smooth the skin surface and improve moisture retention.

Clinical Evidence & References

Research demonstrates that skin ageing involves progressive loss of collagen, thinning of the epidermis and dermis, and declining antioxidant defences. Peptide-based ingredients are designed to address these changes by supporting skin structure and protecting against further oxidative damage.

While the specific clinical evidence for Sh-Polypeptide-62 itself is limited in published literature, peptides as a category have shown promise in supporting skin firmness and texture. Further dedicated research into this particular peptide would strengthen our understanding of its efficacy and optimal use.

How to Use

Sh-Polypeptide-62 is typically incorporated into serums, moisturisers, and conditioning treatments. It works well in layered skincare routines and pairs effectively with other antioxidants and hydrating ingredients. Apply to clean skin and allow to absorb before applying further products. Consistency over time will yield the best results, as peptide benefits accumulate with regular use.

Safety & Precautions

Generally well-tolerated across skin types. Peptides are large molecules unlikely to cause irritation; however, individual sensitivities may vary depending on other formulation ingredients.

Frequently Asked Questions

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