Peptides

Sh-Polypeptide-64

INCI: SH-POLYPEPTIDE-64

Reviewed by Kate · Last updated 2 Jun 2026

A peptide ingredient that combines antioxidant and skin-conditioning properties

Best For Skin Types

All, Dry, Mature, Sensitive

Addresses

Fine lines, Dryness, Barrier repair

Usage Frequency

Daily

What Is Sh-Polypeptide-64?

Sh-Polypeptide-64 is a peptide—a short chain of amino acids—designed to support skin health through multiple pathways. Peptides are naturally occurring in skin and are valued in cosmetic formulations for their ability to interact with skin cells in meaningful ways.

This particular peptide functions as both an antioxidant and a skin conditioner, meaning it works to neutralise oxidative stress whilst also helping to improve the skin's texture and barrier function. It's used in skincare products at relatively modest concentrations to deliver these complementary benefits.

Benefits for Your Skin

How It Works

As an antioxidant, Sh-Polypeptide-64 works by donating electrons to unstable free radical molecules, stabilising them and preventing them from causing oxidative damage to skin cells. This is particularly relevant in environments with pollution, UV exposure, or other stressors.

As a skin conditioner, the peptide interacts with the outer layers of skin to improve hydration retention and surface texture. The amino acid composition of the peptide allows it to support the skin's natural moisturising factor and barrier lipids, helping skin feel and appear more supple.

Clinical Evidence & References

Published clinical data on Sh-Polypeptide-64 specifically remains limited, which is not uncommon for many cosmetic peptides. The ingredient's antioxidant and conditioning properties are consistent with peptide chemistry and the functional profile of similar polypeptides used in skincare.

Evidence for peptides as a category suggests benefits for skin hydration, barrier function, and protection against oxidative stress, though individual efficacy varies by formulation, concentration, and skin type. Further targeted research on this particular peptide would help clarify its specific contribution when used in skincare products.

How to Use

Sh-Polypeptide-64 is typically incorporated into serums, moisturisers, and treatment products at concentrations that complement other actives. It can be used daily as part of a routine and is generally compatible with most other skincare ingredients, including retinoids, vitamin C, and niacinamide. For best results, allow adequate time for a moisturiser or serum containing this peptide to absorb before applying other products.

Safety & Precautions

Sh-Polypeptide-64 is generally well-tolerated and considered safe for topical use in cosmetics. Peptides are large molecules that remain on the skin surface, making adverse reactions uncommon.

Frequently Asked Questions

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