Peptides

Sh-Polypeptide-77

INCI: SH-POLYPEPTIDE-77

Reviewed by Rosie · Last updated 2 Jun 2026

A peptide derivative that supports skin conditioning and structural integrity

Best For Skin Types

All, Mature

Addresses

Fine lines, Firmness, Hydration

Usage Frequency

Daily

What Is Sh-Polypeptide-77?

Sh-Polypeptide-77 is a peptide—a short chain of amino acids—used in skincare formulations primarily for its skin conditioning properties. Peptides are fragments of proteins that can penetrate the skin's outer layers and communicate with skin cells, potentially influencing how the skin behaves and maintains its appearance.

This ingredient functions as a skin conditioning agent, meaning it works to improve the texture, feel, and overall condition of the skin. It is typically incorporated into serums, moisturisers, and treatment products at relatively modest concentrations.

How It Works

Peptides work by penetrating the outer layers of the skin and communicating with skin cells through receptor-binding. Sh-Polypeptide-77 is believed to signal to the skin to maintain or enhance its natural production of structural proteins, particularly those involved in firmness and elasticity.

The peptide also supports the skin's barrier function and hydration capacity, which are essential for healthy skin appearance. By reinforcing these foundational skin properties, the ingredient may help address visible signs of aging and maintain skin resilience over time.

Clinical Evidence & References

Research confirms that skin ages through a combination of intrinsic factors (such as loss of collagen and thinning of the epidermis and dermis) and extrinsic damage. Peptides are recognised in the literature as ingredients that can support skin structure, and specific peptides have demonstrated benefits for skin firmness and hydration.

However, evidence specific to Sh-Polypeptide-77 is limited in the published literature. The ingredient's skin conditioning role is established, but further independent research would help clarify the extent of its benefits for fine lines, firmness, and other signs of aging in human studies.

How to Use

Sh-Polypeptide-77 is typically found in serums and moisturisers designed for mature or aging skin concerns. Apply to clean skin before heavier creams or oils to maximise penetration. It can be used daily as part of your regular skincare routine and pairs well with complementary ingredients such as hydrators and antioxidants.

Safety & Precautions

Peptides are generally well-tolerated and considered safe for topical use. Those with known sensitivities to amino acids or peptide-based ingredients should patch-test first.

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