Sh-Polypeptide-82

Sh-Polypeptide-82 is a peptide—a short chain of amino acids—used in skincare formulations as a skin conditioning agent. Peptides are naturally occurring molecules that play a role in skin structure and function, and those used cosmetically are designed to help maintain and support the skin's condition.This ingredient functions primarily as a humectant and conditioning agent, helping to support the skin's moisture retention and overall appearance. It is typically found in serums, moisturisers, and treatment products where skin conditioning is a priority.

Peptides like Sh-Polypeptide-82 work by binding to the skin's surface and helping to reinforce its moisture barrier. This reduces transepidermal water loss (TEWL)—the natural evaporation of water from the skin—which in turn supports hydration and skin conditioning.As a conditioning agent, this peptide may also interact with skin proteins in ways that help maintain skin structure, though the specific mechanisms remain an area of ongoing research. The ingredient is generally well-suited to products designed for mature or compromised skin.

This ingredient is typically found in leave-on products such as serums and moisturisers. Apply to clean skin, either alone or as part of your routine, once or twice daily depending on product formulation and your skin's needs. Peptide-based products are generally compatible with other skincare actives, though it's sensible to introduce new products gradually if you have sensitive skin.

Peptides are generally well-tolerated by most skin types, including sensitive skin. As with any ingredient, discontinue use if irritation occurs and patch test if you are prone to reactions.